Molecular epidemiology of Fonsecaea pedrosoi using mitochondrial DNA analysis

M Kawasaki, M Aoki, H Ishizaki, M Miyaji, K Nishimura, K Nishimoto, T Matsumoto, C De Vroey, R Negroni, M Mendonca, A Andriantsimahavandy, P Esterre

    Research output: Contribution to journalA1: Web of Science-articlepeer-review

    Abstract

    Restriction fragment length polymorphism (RFLP) of mitochondrial DNA (mtDNA) from 49 clinical Fonsecaea pedrosoi isolates (18 isolates from Japan, 17 from Madagascar, 7 from Argentina, 5 from Venezuela, 1 from Costa Rica and 1 unknown) was studied. The 49 isolates were composed of 20 isolates of Type 1, 16 of Type 2, 12 of Type 4 and 1 of a new mtDNA type, Type 7, which was closely related to Type 2. On the bases of the results of 120 isolates of the present (49 isolates) and previous (71 isolates) studies, F. pedrosoi was classified into seven mtDNA types and according to the relationship between mtDNA types and geographic origins: in Japan and probably in China, Type 1 isolates; in Zaire and Madagascar, Type 2; in Central and South America, Type 4 and Type 1. These results indicated that the geographical origin of F. pedrosoi isolate could be roughly inferred from its mtDNA type.
    Original languageEnglish
    JournalMedical Mycology
    Volume37
    Issue number6
    Pages (from-to)435-440
    ISSN1369-3786
    DOIs
    Publication statusPublished - 1999

    Keywords

    • B780-tropical-medicine
    • Mycology
    • Fonsecaea pedrosoi
    • DNA
    • Epidemiology
    • Molecular

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