Mosquito transgenesis for malaria control

Shengzhang Dong, Yuemei Dong, Maria Luisa Simões, George Dimopoulos

    Research output: Contribution to journalReviewpeer-review


    Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as promising tools for preventing the spread of malaria by either suppressing mosquito populations by self-destructing mosquitoes or replacing mosquito populations with disease-refractory populations. Here we review the development of mosquito transgenesis and its application for malaria control, highlighting the transgenic expression of antiparasitic effector genes, inactivation of host factor genes, and manipulation of miRNAs and lncRNAs. Overall, from a malaria-control perspective, mosquito transgenesis is not envisioned as a stand-alone approach; rather, its use is proposed as a complement to existing vector-control strategies.

    Original languageEnglish
    JournalTrends In Parasitology
    Issue number1
    Pages (from-to)54-66
    Number of pages13
    Publication statusPublished - 2022


    • Animals
    • Anopheles/physiology
    • Gene Transfer Techniques
    • Malaria/parasitology
    • Mosquito Control
    • Mosquito Vectors/genetics


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