Natural Leishmania donovani/Leishmania aethiopica hybrids identified from Ethiopia

S Odiwuor, S De Doncker, I Maes, JC Dujardin, G Van der Auwera

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Natural hybridization events have been demonstrated between closely and distantly related Leishmania groups despite a predominantly clonal and endogamically sexual mode of reproduction. Here we report the first natural hybrid between Leishmania aethiopica and Leishmania donovani, as evidenced from the analysis of several clones from strain MHOM/ET/94/ABAUY. Targeted species-identification PCRs revealed the presence of both genotypes, and amplified fragment length polymorphisms indicated that the clones are genetically in an intermediate position between both parental species, being more closely related to L. aethiopica. The possible scenario facilitating hybrid formation is not clear, but is discussed in relation to epidemiological data.
    Original languageEnglish
    JournalInfection, Genetics and Evolution
    Volume11
    Issue number8
    Pages (from-to)2113-2118
    Number of pages6
    ISSN1567-1348
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Visceral
    • Leishmaniasis
    • Kala azar
    • Leishmania donovani
    • Leishmania aethiopica
    • Vectors
    • Sandflies
    • Hybrids
    • Identification
    • Clones
    • Genotypes
    • Ethiopia
    • Africa-East

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