No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM

Sofie H Mooij, Olivia Landén, Fiona R M van der Klis, Marianne A B van der Sande, Hester E de Melker, Roel A Coutinho, Arne van Eeden, Martijn S van Rooijen, Chris J L M Meijer, Maarten F Schim van der Loeff

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To assess whether HPV serum antibodies detected after natural infection protect against subsequent anal or penile infection with the same HPV type in HIV-negative and HIV-infected men who have sex with men (MSM).

METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed-up semi-annually. Antibodies against 7 high-risk HPV types in baseline serum samples were tested using a multiplex immunoassay; baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA and genotyped using the SPF10-PCR DEIA/LiPA25 system (version 1). Statistical analyses were performed using the Wei-Lin-Weissfeld method.

RESULTS: 719 MSM (median age 40 years; IQR 35-48) with baseline and follow-up data were included in these analyses; 287 (40%) were HIV-infected. HPV seropositivity at baseline was not significantly associated with subsequent type-specific HPV infection at 6 or 12 months in multivariable analyses (for anal infection adjusted hazard ratio (aHR) 1.2; 95% CI 0.9-1.6; for penile infection aHR 0.8; 95% CI 0.6-1.2). High antibody concentrations showed no protective effect against subsequent infection either.

CONCLUSIONS: In a population of highly sexually active, adult MSM, naturally induced HPV antibodies may not protect MSM against subsequent anal or penile HPV infection within one year.

Original languageEnglish
JournalJournal of Infection
Volume69
Issue number4
Pages (from-to)375-86
Number of pages12
ISSN0163-4453
DOIs
Publication statusPublished - 2014

Keywords

  • Adult
  • Antibodies, Viral/blood
  • Anus Diseases/epidemiology
  • HIV Infections/epidemiology
  • Homosexuality, Male
  • Humans
  • Male
  • Middle Aged
  • Netherlands/epidemiology
  • Papillomaviridae/immunology
  • Papillomavirus Infections/epidemiology
  • Penile Diseases/epidemiology

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