No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM

Sofie H Mooij; Olivia Landén; Fiona R M van der Klis; Marianne A B van der Sande; Hester E de Melker; Roel A Coutinho; Arne van Eeden; Martijn S van Rooijen; Chris J L M Meijer; Maarten F Schim van der Loeff

doi:10.1016/j.jinf.2014.06.003

No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM

Sofie H Mooij, Olivia Landén, Fiona R M van der Klis, Marianne A B van der Sande, Hester E de Melker, Roel A Coutinho, Arne van Eeden, Martijn S van Rooijen, Chris J L M Meijer, Maarten F Schim van der Loeff

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

OBJECTIVES: To assess whether HPV serum antibodies detected after natural infection protect against subsequent anal or penile infection with the same HPV type in HIV-negative and HIV-infected men who have sex with men (MSM).

METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed-up semi-annually. Antibodies against 7 high-risk HPV types in baseline serum samples were tested using a multiplex immunoassay; baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA and genotyped using the SPF10-PCR DEIA/LiPA25 system (version 1). Statistical analyses were performed using the Wei-Lin-Weissfeld method.

RESULTS: 719 MSM (median age 40 years; IQR 35-48) with baseline and follow-up data were included in these analyses; 287 (40%) were HIV-infected. HPV seropositivity at baseline was not significantly associated with subsequent type-specific HPV infection at 6 or 12 months in multivariable analyses (for anal infection adjusted hazard ratio (aHR) 1.2; 95% CI 0.9-1.6; for penile infection aHR 0.8; 95% CI 0.6-1.2). High antibody concentrations showed no protective effect against subsequent infection either.

CONCLUSIONS: In a population of highly sexually active, adult MSM, naturally induced HPV antibodies may not protect MSM against subsequent anal or penile HPV infection within one year.

Original language	English
Journal	Journal of Infection
Volume	69
Issue number	4
Pages (from-to)	375-386
Number of pages	12
ISSN	0163-4453
DOIs	https://doi.org/10.1016/j.jinf.2014.06.003
Publication status	Published - 2014

Keywords

Adult
Antibodies, Viral/blood
Anus Diseases/epidemiology
HIV Infections/epidemiology
Homosexuality, Male
Humans
Male
Middle Aged
Netherlands/epidemiology
Papillomaviridae/immunology
Papillomavirus Infections/epidemiology
Penile Diseases/epidemiology

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10.1016/j.jinf.2014.06.003

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Mooij, S. H., Landén, O., van der Klis, F. R. M., van der Sande, M. A. B., de Melker, H. E., Coutinho, R. A., van Eeden, A., van Rooijen, M. S., Meijer, C. J. L. M., & Schim van der Loeff, M. F. (2014). No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM. Journal of Infection, 69(4), 375-386. https://doi.org/10.1016/j.jinf.2014.06.003

@article{2dc2828f579446bb9e1b6163d8235bd8,

title = "No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM",

abstract = "OBJECTIVES: To assess whether HPV serum antibodies detected after natural infection protect against subsequent anal or penile infection with the same HPV type in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed-up semi-annually. Antibodies against 7 high-risk HPV types in baseline serum samples were tested using a multiplex immunoassay; baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA and genotyped using the SPF10-PCR DEIA/LiPA25 system (version 1). Statistical analyses were performed using the Wei-Lin-Weissfeld method.RESULTS: 719 MSM (median age 40 years; IQR 35-48) with baseline and follow-up data were included in these analyses; 287 (40%) were HIV-infected. HPV seropositivity at baseline was not significantly associated with subsequent type-specific HPV infection at 6 or 12 months in multivariable analyses (for anal infection adjusted hazard ratio (aHR) 1.2; 95% CI 0.9-1.6; for penile infection aHR 0.8; 95% CI 0.6-1.2). High antibody concentrations showed no protective effect against subsequent infection either.CONCLUSIONS: In a population of highly sexually active, adult MSM, naturally induced HPV antibodies may not protect MSM against subsequent anal or penile HPV infection within one year.",

keywords = "Adult, Antibodies, Viral/blood, Anus Diseases/epidemiology, HIV Infections/epidemiology, Homosexuality, Male, Humans, Male, Middle Aged, Netherlands/epidemiology, Papillomaviridae/immunology, Papillomavirus Infections/epidemiology, Penile Diseases/epidemiology",

author = "Mooij, {Sofie H} and Olivia Land{\'e}n and {van der Klis}, {Fiona R M} and {van der Sande}, {Marianne A B} and {de Melker}, {Hester E} and Coutinho, {Roel A} and {van Eeden}, Arne and {van Rooijen}, {Martijn S} and Meijer, {Chris J L M} and {Schim van der Loeff}, {Maarten F}",

year = "2014",

doi = "10.1016/j.jinf.2014.06.003",

language = "English",

volume = "69",

pages = "375--386",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "4",

}

Mooij, SH, Landén, O, van der Klis, FRM, van der Sande, MAB, de Melker, HE, Coutinho, RA, van Eeden, A, van Rooijen, MS, Meijer, CJLM & Schim van der Loeff, MF 2014, 'No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM', Journal of Infection, vol. 69, no. 4, pp. 375-386. https://doi.org/10.1016/j.jinf.2014.06.003

TY - JOUR

T1 - No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM

AU - Mooij, Sofie H

AU - Landén, Olivia

AU - van der Klis, Fiona R M

AU - van der Sande, Marianne A B

AU - de Melker, Hester E

AU - Coutinho, Roel A

AU - van Eeden, Arne

AU - van Rooijen, Martijn S

AU - Meijer, Chris J L M

AU - Schim van der Loeff, Maarten F

PY - 2014

Y1 - 2014

N2 - OBJECTIVES: To assess whether HPV serum antibodies detected after natural infection protect against subsequent anal or penile infection with the same HPV type in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed-up semi-annually. Antibodies against 7 high-risk HPV types in baseline serum samples were tested using a multiplex immunoassay; baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA and genotyped using the SPF10-PCR DEIA/LiPA25 system (version 1). Statistical analyses were performed using the Wei-Lin-Weissfeld method.RESULTS: 719 MSM (median age 40 years; IQR 35-48) with baseline and follow-up data were included in these analyses; 287 (40%) were HIV-infected. HPV seropositivity at baseline was not significantly associated with subsequent type-specific HPV infection at 6 or 12 months in multivariable analyses (for anal infection adjusted hazard ratio (aHR) 1.2; 95% CI 0.9-1.6; for penile infection aHR 0.8; 95% CI 0.6-1.2). High antibody concentrations showed no protective effect against subsequent infection either.CONCLUSIONS: In a population of highly sexually active, adult MSM, naturally induced HPV antibodies may not protect MSM against subsequent anal or penile HPV infection within one year.

AB - OBJECTIVES: To assess whether HPV serum antibodies detected after natural infection protect against subsequent anal or penile infection with the same HPV type in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed-up semi-annually. Antibodies against 7 high-risk HPV types in baseline serum samples were tested using a multiplex immunoassay; baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA and genotyped using the SPF10-PCR DEIA/LiPA25 system (version 1). Statistical analyses were performed using the Wei-Lin-Weissfeld method.RESULTS: 719 MSM (median age 40 years; IQR 35-48) with baseline and follow-up data were included in these analyses; 287 (40%) were HIV-infected. HPV seropositivity at baseline was not significantly associated with subsequent type-specific HPV infection at 6 or 12 months in multivariable analyses (for anal infection adjusted hazard ratio (aHR) 1.2; 95% CI 0.9-1.6; for penile infection aHR 0.8; 95% CI 0.6-1.2). High antibody concentrations showed no protective effect against subsequent infection either.CONCLUSIONS: In a population of highly sexually active, adult MSM, naturally induced HPV antibodies may not protect MSM against subsequent anal or penile HPV infection within one year.

KW - Adult

KW - Antibodies, Viral/blood

KW - Anus Diseases/epidemiology

KW - HIV Infections/epidemiology

KW - Homosexuality, Male

KW - Humans

KW - Male

KW - Middle Aged

KW - Netherlands/epidemiology

KW - Papillomaviridae/immunology

KW - Papillomavirus Infections/epidemiology

KW - Penile Diseases/epidemiology

U2 - 10.1016/j.jinf.2014.06.003

DO - 10.1016/j.jinf.2014.06.003

M3 - A1: Web of Science-article

C2 - 24931579

SN - 0163-4453

VL - 69

SP - 375

EP - 386

JO - Journal of Infection

JF - Journal of Infection

IS - 4

ER -

No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM

Abstract

Keywords

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