No evidence for cross-protection of the HPV-16/18 vaccine against HPV-6/11 positivity in female STI clinic visitors

Medical Microbiological Laboratories

Research output: Contribution to journalA1: Web of Science-article

Abstract

OBJECTIVES: Data from a vaccine trial and from post-vaccine surveillance in the United Kingdom have suggested that the bivalent HPV-16/18 vaccine offers cross-protection against HPV-6/11 and protection against anogenital warts (AGW). We studied the effect of the bivalent vaccine on genital HPV-6/11 positivity and AGW in the Netherlands.

METHODS: We included all vaccine-eligible women from the PASSYON study, a biennial cross-sectional study among 16- to 24-year-old sexually transmitted infection (STI) clinic attendants. Vaginal self-swabs were analyzed for type specific HPV and AGW were diagnosed at the STI-clinic. Prevalence of HPV-6 and/or HPV-11 and AGW were compared between self-reported vaccinated and unvaccinated women by log-binomial regression analysis, adjusted for demographics and risk behavior.

RESULTS: Of the 1198 women included, 56% reported to be vaccinated at least once. Relative to unvaccinated women, the adjusted prevalence ratio (PR) for HPV-6/11 was 1.03 (95% confidence interval [CI] 0.74-1.43) for women vaccinated at least once. The crude PR for AGW was 0.67 (95% CI 0.22-2.07) for women vaccinated at least once. Adjustment did not change these results.

CONCLUSIONS: We observed no cross-protective effect of the bivalent vaccine on genital HPV-6/11 positivity and a non-significant partially protective effect on AGW.

Original languageEnglish
JournalJournal of Infection
Volume74
Issue number4
Pages (from-to)393-400
Number of pages8
ISSN0163-4453
DOIs
Publication statusPublished - 2017

Keywords

  • Adolescent
  • Adult
  • Ambulatory Care Facilities
  • Condylomata Acuminata/prevention & control
  • Cross Protection
  • Cross-Sectional Studies
  • Female
  • Human papillomavirus 11/immunology
  • Human papillomavirus 16/immunology
  • Human papillomavirus 18/immunology
  • Human papillomavirus 6/immunology
  • Humans
  • Netherlands/epidemiology
  • Papillomavirus Infections/epidemiology
  • Papillomavirus Vaccines/immunology
  • Prevalence
  • Sexually Transmitted Diseases/prevention & control
  • United Kingdom/epidemiology
  • Uterine Cervical Neoplasms/prevention & control
  • Vagina/virology
  • Young Adult

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