Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia

Maryline Bonnet; Kim Chamroeun San; Yati Pho; Chandara Sok; Jean-Philippe Dousset; William Brant; Northan Hurtado; Khun Kim Eam; Elisa Ardizzoni; Seiha Heng; Sylvain Godreuil; Wing-Wai Yew; Cathy Hewison

doi:10.3201/eid2307.170060

Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia

Maryline Bonnet, Kim Chamroeun San, Yati Pho, Chandara Sok, Jean-Philippe Dousset, William Brant, Northan Hurtado, Khun Kim Eam, Elisa Ardizzoni, Seiha Heng, Sylvain Godreuil, Wing-Wai Yew, Cathy Hewison

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

9 Downloads (Pure)

Abstract

Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >= 12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.

Original language	English
Journal	Emerging Infectious Diseases
Volume	23
Issue number	7
Pages (from-to)	1139-1147
Number of pages	9
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2307.170060
Publication status	Published - 2017

Keywords

HUMAN PULMONARY INFECTION
AFRICAN GOLD MINERS
RISK-FACTORS
LUNG-DISEASE
EPIDEMIOLOGY
TUBERCULOSIS
DIAGNOSIS
CULTURE
ZAMBIA
ASIA

Access to Document

10.3201/eid2307.170060Licence: Unspecified

2017eidi1139Licence: Unspecified

Cite this

Bonnet, Maryline ; San, Kim Chamroeun ; Pho, Yati ; Sok, Chandara ; Dousset, Jean-Philippe ; Brant, William ; Hurtado, Northan ; Eam, Khun Kim ; Ardizzoni, Elisa ; Heng, Seiha ; Godreuil, Sylvain ; Yew, Wing-Wai ; Hewison, Cathy. / Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia. In: Emerging Infectious Diseases. 2017 ; Vol. 23, No. 7. pp. 1139-1147.

@article{e694a265e5d0449c8554958487e07d57,

title = "Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia",

abstract = "Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >= 12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.",

keywords = "HUMAN PULMONARY INFECTION, AFRICAN GOLD MINERS, RISK-FACTORS, LUNG-DISEASE, EPIDEMIOLOGY, TUBERCULOSIS, DIAGNOSIS, CULTURE, ZAMBIA, ASIA",

author = "Maryline Bonnet and San, {Kim Chamroeun} and Yati Pho and Chandara Sok and Jean-Philippe Dousset and William Brant and Northan Hurtado and Eam, {Khun Kim} and Elisa Ardizzoni and Seiha Heng and Sylvain Godreuil and Wing-Wai Yew and Cathy Hewison",

note = "FTX; DOAJ",

year = "2017",

doi = "10.3201/eid2307.170060",

language = "English",

volume = "23",

pages = "1139--1147",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "7",

}

Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia. / Bonnet, Maryline; San, Kim Chamroeun; Pho, Yati; Sok, Chandara; Dousset, Jean-Philippe; Brant, William; Hurtado, Northan; Eam, Khun Kim; Ardizzoni, Elisa; Heng, Seiha; Godreuil, Sylvain; Yew, Wing-Wai; Hewison, Cathy.

In: Emerging Infectious Diseases, Vol. 23, No. 7, 2017, p. 1139-1147.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Nontuberculous Mycobacteria infections at a provincial reference hospital, Cambodia

AU - Bonnet, Maryline

AU - San, Kim Chamroeun

AU - Pho, Yati

AU - Sok, Chandara

AU - Dousset, Jean-Philippe

AU - Brant, William

AU - Hurtado, Northan

AU - Eam, Khun Kim

AU - Ardizzoni, Elisa

AU - Heng, Seiha

AU - Godreuil, Sylvain

AU - Yew, Wing-Wai

AU - Hewison, Cathy

N1 - FTX; DOAJ

PY - 2017

Y1 - 2017

N2 - Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >= 12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.

AB - Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >= 12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.

KW - HUMAN PULMONARY INFECTION

KW - AFRICAN GOLD MINERS

KW - RISK-FACTORS

KW - LUNG-DISEASE

KW - EPIDEMIOLOGY

KW - TUBERCULOSIS

KW - DIAGNOSIS

KW - CULTURE

KW - ZAMBIA

KW - ASIA

U2 - 10.3201/eid2307.170060

DO - 10.3201/eid2307.170060

M3 - A1: Web of Science-article

VL - 23

SP - 1139

EP - 1147

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 7

ER -