Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

Basil Britto Xavier; Jasmine Coppens; Sien De Koster; Sahaya Glingston Rajakani; Sam Van Goethem; Samy Mzougui; Ahalieyah Anantharajah; Christine Lammens; Katherine Loens; Youri Glupczynski; Herman Goossens; Veerle Matheeussen

doi:10.2807/1560-7917.ES.2021.26.36.2100767

Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

Basil Britto Xavier, Jasmine Coppens, Sien De Koster, Sahaya Glingston Rajakani, Sam Van Goethem, Samy Mzougui, Ahalieyah Anantharajah, Christine Lammens, Katherine Loens, Youri Glupczynski, Herman Goossens, Veerle Matheeussen

Clinical Reference Laboratory

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Abstract

We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridiumscidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

Original language	English
Article number	2100767
Journal	Eurosurveillance
Volume	26
Issue number	36
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2021.26.36.2100767
Publication status	Published - 2021

Keywords

Anti-Bacterial Agents/pharmacology
Bacterial Proteins/genetics
Belgium
Enterococcus faecium/genetics
Humans
Multigene Family
Vancomycin Resistance/genetics

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10.2807/1560-7917.ES.2021.26.36.2100767Licence: CC BY

2021euro2100767Final published version, 2.6 MBLicence: CC BY

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Xavier, B. B., Coppens, J., De Koster, S., Rajakani, S. G., Van Goethem, S., Mzougui, S., Anantharajah, A., Lammens, C., Loens, K., Glupczynski, Y., Goossens, H., & Matheeussen, V. (2021). Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021. Eurosurveillance, 26(36), Article 2100767. https://doi.org/10.2807/1560-7917.ES.2021.26.36.2100767

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title = "Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021",

abstract = "We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridiumscidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.",

keywords = "Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Belgium, Enterococcus faecium/genetics, Humans, Multigene Family, Vancomycin Resistance/genetics",

author = "Xavier, {Basil Britto} and Jasmine Coppens and {De Koster}, Sien and Rajakani, {Sahaya Glingston} and {Van Goethem}, Sam and Samy Mzougui and Ahalieyah Anantharajah and Christine Lammens and Katherine Loens and Youri Glupczynski and Herman Goossens and Veerle Matheeussen",

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doi = "10.2807/1560-7917.ES.2021.26.36.2100767",

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T1 - Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

AU - Xavier, Basil Britto

AU - Coppens, Jasmine

AU - De Koster, Sien

AU - Rajakani, Sahaya Glingston

AU - Van Goethem, Sam

AU - Mzougui, Samy

AU - Anantharajah, Ahalieyah

AU - Lammens, Christine

AU - Loens, Katherine

AU - Glupczynski, Youri

AU - Goossens, Herman

AU - Matheeussen, Veerle

N1 - FTX; DOAJ; (CC BY 4.0)

PY - 2021

Y1 - 2021

N2 - We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridiumscidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

AB - We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridiumscidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

KW - Anti-Bacterial Agents/pharmacology

KW - Bacterial Proteins/genetics

KW - Belgium

KW - Enterococcus faecium/genetics

KW - Humans

KW - Multigene Family

KW - Vancomycin Resistance/genetics

U2 - 10.2807/1560-7917.ES.2021.26.36.2100767

DO - 10.2807/1560-7917.ES.2021.26.36.2100767

M3 - A1: Web of Science-article

C2 - 34505571

SN - 1560-7917

VL - 26

JO - Eurosurveillance

JF - Eurosurveillance

IS - 36

M1 - 2100767

ER -

Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

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