Options for improvement of the Dutch measles vaccination schedule

S van den Hof; J Wallinga; M-A Widdowson; M A E Conyn-van Spaendonck

doi:10.1016/s0264-410x(02)00588-1

Options for improvement of the Dutch measles vaccination schedule

S van den Hof, J Wallinga, M-A Widdowson, M A E Conyn-van Spaendonck

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

We investigated which vaccination schedule gives best protection to the vaccinating population, in case of a measles epidemic in pockets of unvaccinated individuals. We explored the effect of an additional measles vaccination (at 6 or 9 months), advancing the first measles-mumps-rubella (MMR) vaccination from 14 to 11 months, and advancing the second MMR from 9 to 4 years. Measures of protection among vaccinees (percentage of susceptibles, number of reported cases, percentage of lifetime spent susceptible) were estimated with a mathematical model of the impact of antibody level on seroconversion and immunity. Advancing the age of second MMR vaccination prevents considerably more cases among vaccinees than an extra early measles vaccination or advancing the age of first MMR vaccination.

Original language	English
Journal	Vaccine
Volume	21
Issue number	7-8
Pages (from-to)	721-4
Number of pages	4
ISSN	0264-410X
DOIs	https://doi.org/10.1016/s0264-410x(02)00588-1
Publication status	Published - 2003

Keywords

Child, Preschool
Humans
Immunization Schedule
Infant
Measles/epidemiology
Measles-Mumps-Rubella Vaccine/administration & dosage
Netherlands/epidemiology

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10.1016/s0264-410x(02)00588-1

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title = "Options for improvement of the Dutch measles vaccination schedule",

abstract = "We investigated which vaccination schedule gives best protection to the vaccinating population, in case of a measles epidemic in pockets of unvaccinated individuals. We explored the effect of an additional measles vaccination (at 6 or 9 months), advancing the first measles-mumps-rubella (MMR) vaccination from 14 to 11 months, and advancing the second MMR from 9 to 4 years. Measures of protection among vaccinees (percentage of susceptibles, number of reported cases, percentage of lifetime spent susceptible) were estimated with a mathematical model of the impact of antibody level on seroconversion and immunity. Advancing the age of second MMR vaccination prevents considerably more cases among vaccinees than an extra early measles vaccination or advancing the age of first MMR vaccination.",

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doi = "10.1016/s0264-410x(02)00588-1",

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journal = "Vaccine",

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TY - JOUR

T1 - Options for improvement of the Dutch measles vaccination schedule

AU - van den Hof, S

AU - Wallinga, J

AU - Widdowson, M-A

AU - Conyn-van Spaendonck, M A E

PY - 2003

Y1 - 2003

N2 - We investigated which vaccination schedule gives best protection to the vaccinating population, in case of a measles epidemic in pockets of unvaccinated individuals. We explored the effect of an additional measles vaccination (at 6 or 9 months), advancing the first measles-mumps-rubella (MMR) vaccination from 14 to 11 months, and advancing the second MMR from 9 to 4 years. Measures of protection among vaccinees (percentage of susceptibles, number of reported cases, percentage of lifetime spent susceptible) were estimated with a mathematical model of the impact of antibody level on seroconversion and immunity. Advancing the age of second MMR vaccination prevents considerably more cases among vaccinees than an extra early measles vaccination or advancing the age of first MMR vaccination.

AB - We investigated which vaccination schedule gives best protection to the vaccinating population, in case of a measles epidemic in pockets of unvaccinated individuals. We explored the effect of an additional measles vaccination (at 6 or 9 months), advancing the first measles-mumps-rubella (MMR) vaccination from 14 to 11 months, and advancing the second MMR from 9 to 4 years. Measures of protection among vaccinees (percentage of susceptibles, number of reported cases, percentage of lifetime spent susceptible) were estimated with a mathematical model of the impact of antibody level on seroconversion and immunity. Advancing the age of second MMR vaccination prevents considerably more cases among vaccinees than an extra early measles vaccination or advancing the age of first MMR vaccination.

KW - Child, Preschool

KW - Humans

KW - Immunization Schedule

KW - Infant

KW - Measles/epidemiology

KW - Measles-Mumps-Rubella Vaccine/administration & dosage

KW - Netherlands/epidemiology

U2 - 10.1016/s0264-410x(02)00588-1

DO - 10.1016/s0264-410x(02)00588-1

M3 - A1: Web of Science-article

C2 - 12531348

SN - 0264-410X

VL - 21

SP - 721

EP - 724

JO - Vaccine

JF - Vaccine

IS - 7-8

ER -

Options for improvement of the Dutch measles vaccination schedule

Abstract

Keywords

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