Options for the delivery of anti-pathogen molecules in arthropod vectors

G. Caljon, L. De Vooght, J. Van Den Abbeele

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Blood feeding arthropods are responsible for the transmission of a large array of medically important infectious agents that include viruses, bacteria, protozoan parasites and helminths. The recent development of transgenic and paratransgenic technologies have enabled supplementing the immune system of these arthropod vectors with anti-pathogen effector molecules in view of compromising their vector competence for these microbial agents. The characteristics of the selected anti-pathogen compound will largely determine the efficacy and specificity of this approach. Low specificity will generally result in bystander effects, likely having a direct or indirect fitness cost for the arthropod. In contrast, the use of highly specific compounds from the adaptive immune system of vertebrates such as antibody derived fragments is more likely to enable highly specific effects without conferring a selective disadvantage to the (para)transgenic arthropods. Here, Nanobodies(R) are excellent candidates to increase the immune competence of arthropods. Moreover they were shown to exert a novel type of anti-pathogen activity that uniquely depends on their small size.
    Original languageEnglish
    JournalJournal of Invertebrate Pathology
    Volume112
    Issue numberS1
    Pages (from-to)S75-S82
    Number of pages7
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Vector-borne diseases
    • Malaria
    • Plasmodium falciparum
    • Trypanosomiasis-African
    • Sleeping sickness
    • Trypanosoma brucei
    • Vectors
    • Arthropods
    • Tsetse flies
    • Rhodnius prolixus
    • Aedes aegypti
    • Aedes fluvialitis
    • Anopheles gambiae
    • Anopheles stephensi
    • Vectorial competence
    • Antiprotozoal agents
    • Molecular cloning
    • Transgenesis
    • Nanobodies
    • Innate immunity
    • Inhibition
    • Research
    • Review of the literature

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