Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

Sofie H Mooij; Hein J Boot; Arjen G C L Speksnijder; Ineke G Stolte; Chris J L M Meijer; Peter J F Snijders; Dominique W M Verhagen; Audrey J King; Henry J C de Vries; Wim G V Quint; Marianne van der Sande; Maarten F Schim van der Loeff

doi:10.1097/QAD.0b013e328362395c

Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

Sofie H Mooij, Hein J Boot, Arjen G C L Speksnijder, Ineke G Stolte, Chris J L M Meijer, Peter J F Snijders, Dominique W M Verhagen, Audrey J King, Henry J C de Vries, Wim G V Quint, Marianne van der Sande, Maarten F Schim van der Loeff

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.

DESIGN: Analysis of baseline data from a prospective cohort study.

METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].

RESULTS: In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.

CONCLUSION: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

Original language	English
Journal	AIDS
Volume	27
Issue number	13
Pages (from-to)	2117-2128
Number of pages	12
ISSN	0269-9370
DOIs	https://doi.org/10.1097/QAD.0b013e328362395c
Publication status	Published - 2013

Keywords

Adult
Cohort Studies
DNA, Viral/genetics
HIV Infections/complications
Homosexuality, Male
Humans
Immunoenzyme Techniques
Male
Middle Aged
Mouth/virology
Mouth Diseases/epidemiology
Netherlands
Papillomaviridae/genetics
Papillomavirus Infections/epidemiology
Polymerase Chain Reaction
Prevalence
Retrospective Studies
Risk Factors
Surveys and Questionnaires
Young Adult

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10.1097/QAD.0b013e328362395c

Cite this

Mooij, S. H., Boot, H. J., Speksnijder, A. G. C. L., Stolte, I. G., Meijer, C. J. L. M., Snijders, P. J. F., Verhagen, D. W. M., King, A. J., de Vries, H. J. C., Quint, W. G. V., van der Sande, M., & Schim van der Loeff, M. F. (2013). Oral human papillomavirus infection in HIV-negative and HIV-infected MSM. AIDS, 27(13), 2117-2128. https://doi.org/10.1097/QAD.0b013e328362395c

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title = "Oral human papillomavirus infection in HIV-negative and HIV-infected MSM",

abstract = "OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.DESIGN: Analysis of baseline data from a prospective cohort study.METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].RESULTS: In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.CONCLUSION: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.",

keywords = "Adult, Cohort Studies, DNA, Viral/genetics, HIV Infections/complications, Homosexuality, Male, Humans, Immunoenzyme Techniques, Male, Middle Aged, Mouth/virology, Mouth Diseases/epidemiology, Netherlands, Papillomaviridae/genetics, Papillomavirus Infections/epidemiology, Polymerase Chain Reaction, Prevalence, Retrospective Studies, Risk Factors, Surveys and Questionnaires, Young Adult",

author = "Mooij, {Sofie H} and Boot, {Hein J} and Speksnijder, {Arjen G C L} and Stolte, {Ineke G} and Meijer, {Chris J L M} and Snijders, {Peter J F} and Verhagen, {Dominique W M} and King, {Audrey J} and {de Vries}, {Henry J C} and Quint, {Wim G V} and {van der Sande}, Marianne and {Schim van der Loeff}, {Maarten F}",

note = "NPP",

year = "2013",

doi = "10.1097/QAD.0b013e328362395c",

language = "English",

volume = "27",

pages = "2117--2128",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

number = "13",

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TY - JOUR

T1 - Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

AU - Mooij, Sofie H

AU - Boot, Hein J

AU - Speksnijder, Arjen G C L

AU - Stolte, Ineke G

AU - Meijer, Chris J L M

AU - Snijders, Peter J F

AU - Verhagen, Dominique W M

AU - King, Audrey J

AU - de Vries, Henry J C

AU - Quint, Wim G V

AU - van der Sande, Marianne

AU - Schim van der Loeff, Maarten F

N1 - NPP

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.DESIGN: Analysis of baseline data from a prospective cohort study.METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].RESULTS: In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.CONCLUSION: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

AB - OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.DESIGN: Analysis of baseline data from a prospective cohort study.METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].RESULTS: In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.CONCLUSION: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

KW - Adult

KW - Cohort Studies

KW - DNA, Viral/genetics

KW - HIV Infections/complications

KW - Homosexuality, Male

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Middle Aged

KW - Mouth/virology

KW - Mouth Diseases/epidemiology

KW - Netherlands

KW - Papillomaviridae/genetics

KW - Papillomavirus Infections/epidemiology

KW - Polymerase Chain Reaction

KW - Prevalence

KW - Retrospective Studies

KW - Risk Factors

KW - Surveys and Questionnaires

KW - Young Adult

U2 - 10.1097/QAD.0b013e328362395c

DO - 10.1097/QAD.0b013e328362395c

M3 - A1: Web of Science-article

C2 - 24384590

SN - 0269-9370

VL - 27

SP - 2117

EP - 2128

JO - AIDS

JF - AIDS

IS - 13

ER -

Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

Abstract

Keywords

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