Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

Sofie H Mooij, Hein J Boot, Arjen G C L Speksnijder, Ineke G Stolte, Chris J L M Meijer, Peter J F Snijders, Dominique W M Verhagen, Audrey J King, Henry J C de Vries, Wim G V Quint, Marianne A B van der Sande, Maarten F Schim van der Loeff

Research output: Contribution to journalA1: Web of Science-article

Abstract

OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.

DESIGN: Analysis of baseline data from a prospective cohort study.

METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].

RESULTS: In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.

CONCLUSION: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

Original languageEnglish
JournalAIDS
Volume27
Issue number13
Pages (from-to)2117-2128
Number of pages12
ISSN0269-9370
DOIs
Publication statusPublished - 2013

Keywords

  • Adult
  • Cohort Studies
  • DNA, Viral/genetics
  • HIV Infections/complications
  • Homosexuality, Male
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Mouth/virology
  • Mouth Diseases/epidemiology
  • Netherlands
  • Papillomaviridae/genetics
  • Papillomavirus Infections/epidemiology
  • Polymerase Chain Reaction
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Young Adult

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