Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

Michel Kaswa Kayomo, Epco Hasker, Muriel Aloni, Leontine Nkuku, Marcel Kazadi, Thierry Kabengele, Dorcas Muteteke, Francois Kapita, Alphonse Lufulwabo, Ya Diul Mukadi, Jean-Jacques Muyembe-Tamfum, Margareta Ieven, Bouke C. de Jong, Marleen Boelaert

Research output: Contribution to journalA1: Web of Science-article

Abstract

After an alert regarding approximate to 31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the Mycobacterium tuberculosis isolates' drug-susceptibility patterns and risk factors for TB infection. Among a prison population of 918 inmates, 29 TB case-patients were already undergoing treatment. We found an additional 475 presumptive TB case-patients and confirmed TB in 170 of them. In March 2015, the prevalence rate of confirmed TB was 21.7% (199/918 inmates). We detected an additional 14 cases of rifampin-resistant TB and initiated treatment in all 14 of these case-patients. Overcrowded living conditions and poor nutrition appeared to be the driving factors behind the high TB incidence in this prison.

Original languageEnglish
JournalEmerging Infectious Diseases
Volume24
Issue number11
Pages (from-to)2029-2035
Number of pages7
ISSN1080-6040
DOIs
Publication statusPublished - 2018

Keywords

  • Adolescent
  • Adult
  • Democratic Republic of the Congo/epidemiology
  • Demography
  • Disease Outbreaks
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis/drug effects
  • Prevalence
  • Risk Factors
  • Sputum/microbiology
  • Tuberculosis/epidemiology
  • Tuberculosis, Multidrug-Resistant/epidemiology
  • Young Adult

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