Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

Michel Kaswa Kayomo; Epco Hasker; Muriel Aloni; Leontine Nkuku; Marcel Kazadi; Thierry Kabengele; Dorcas Muteteke; Francois Kapita; Alphonse Lufulwabo; Ya Diul Mukadi; Jean-Jacques Muyembe-Tamfum; Margareta Ieven; Bouke C. de Jong; Marleen Boelaert

doi:10.3201/eid2411.180769

Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

Michel Kaswa Kayomo, Epco Hasker, Muriel Aloni, Leontine Nkuku, Marcel Kazadi, Thierry Kabengele, Dorcas Muteteke, Francois Kapita, Alphonse Lufulwabo, Ya Diul Mukadi, Jean-Jacques Muyembe-Tamfum, Margareta Ieven, Bouke C. de Jong, Marleen Boelaert

Mycobacteriology

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Abstract

After an alert regarding approximate to 31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the Mycobacterium tuberculosis isolates' drug-susceptibility patterns and risk factors for TB infection. Among a prison population of 918 inmates, 29 TB case-patients were already undergoing treatment. We found an additional 475 presumptive TB case-patients and confirmed TB in 170 of them. In March 2015, the prevalence rate of confirmed TB was 21.7% (199/918 inmates). We detected an additional 14 cases of rifampin-resistant TB and initiated treatment in all 14 of these case-patients. Overcrowded living conditions and poor nutrition appeared to be the driving factors behind the high TB incidence in this prison.

Original language	English
Journal	Emerging Infectious Diseases
Volume	24
Issue number	11
Pages (from-to)	2029-2035
Number of pages	7
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2411.180769
Publication status	Published - 2018

Keywords

Adolescent
Adult
Democratic Republic of the Congo/epidemiology
Demography
Disease Outbreaks
Female
Humans
Incidence
Male
Middle Aged
Mycobacterium tuberculosis/drug effects
Prevalence
Risk Factors
Sputum/microbiology
Tuberculosis/epidemiology
Tuberculosis, Multidrug-Resistant/epidemiology
Young Adult

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Kayomo, M. K., Hasker, E., Aloni, M., Nkuku, L., Kazadi, M., Kabengele, T., Muteteke, D., Kapita, F., Lufulwabo, A., Mukadi, Y. D., Muyembe-Tamfum, J.-J., Ieven, M., de Jong, B. C., & Boelaert, M. (2018). Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo. Emerging Infectious Diseases, 24(11), 2029-2035. https://doi.org/10.3201/eid2411.180769

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title = "Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo",

abstract = "After an alert regarding approximate to 31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the Mycobacterium tuberculosis isolates' drug-susceptibility patterns and risk factors for TB infection. Among a prison population of 918 inmates, 29 TB case-patients were already undergoing treatment. We found an additional 475 presumptive TB case-patients and confirmed TB in 170 of them. In March 2015, the prevalence rate of confirmed TB was 21.7% (199/918 inmates). We detected an additional 14 cases of rifampin-resistant TB and initiated treatment in all 14 of these case-patients. Overcrowded living conditions and poor nutrition appeared to be the driving factors behind the high TB incidence in this prison.",

keywords = "Adolescent, Adult, Democratic Republic of the Congo/epidemiology, Demography, Disease Outbreaks, Female, Humans, Incidence, Male, Middle Aged, Mycobacterium tuberculosis/drug effects, Prevalence, Risk Factors, Sputum/microbiology, Tuberculosis/epidemiology, Tuberculosis, Multidrug-Resistant/epidemiology, Young Adult",

author = "Kayomo, {Michel Kaswa} and Epco Hasker and Muriel Aloni and Leontine Nkuku and Marcel Kazadi and Thierry Kabengele and Dorcas Muteteke and Francois Kapita and Alphonse Lufulwabo and Mukadi, {Ya Diul} and Jean-Jacques Muyembe-Tamfum and Margareta Ieven and {de Jong}, {Bouke C.} and Marleen Boelaert",

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year = "2018",

doi = "10.3201/eid2411.180769",

language = "English",

volume = "24",

pages = "2029--2035",

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Kayomo, MK, Hasker, E, Aloni, M, Nkuku, L, Kazadi, M, Kabengele, T, Muteteke, D, Kapita, F, Lufulwabo, A, Mukadi, YD, Muyembe-Tamfum, J-J, Ieven, M, de Jong, BC & Boelaert, M 2018, 'Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo', Emerging Infectious Diseases, vol. 24, no. 11, pp. 2029-2035. https://doi.org/10.3201/eid2411.180769

TY - JOUR

T1 - Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

AU - Kayomo, Michel Kaswa

AU - Hasker, Epco

AU - Aloni, Muriel

AU - Nkuku, Leontine

AU - Kazadi, Marcel

AU - Kabengele, Thierry

AU - Muteteke, Dorcas

AU - Kapita, Francois

AU - Lufulwabo, Alphonse

AU - Mukadi, Ya Diul

AU - Muyembe-Tamfum, Jean-Jacques

AU - Ieven, Margareta

AU - de Jong, Bouke C.

AU - Boelaert, Marleen

N1 - FTX ; DOAJ

PY - 2018

Y1 - 2018

N2 - After an alert regarding approximate to 31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the Mycobacterium tuberculosis isolates' drug-susceptibility patterns and risk factors for TB infection. Among a prison population of 918 inmates, 29 TB case-patients were already undergoing treatment. We found an additional 475 presumptive TB case-patients and confirmed TB in 170 of them. In March 2015, the prevalence rate of confirmed TB was 21.7% (199/918 inmates). We detected an additional 14 cases of rifampin-resistant TB and initiated treatment in all 14 of these case-patients. Overcrowded living conditions and poor nutrition appeared to be the driving factors behind the high TB incidence in this prison.

AB - After an alert regarding approximate to 31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xpert MTB/RIF assay. We also assessed the Mycobacterium tuberculosis isolates' drug-susceptibility patterns and risk factors for TB infection. Among a prison population of 918 inmates, 29 TB case-patients were already undergoing treatment. We found an additional 475 presumptive TB case-patients and confirmed TB in 170 of them. In March 2015, the prevalence rate of confirmed TB was 21.7% (199/918 inmates). We detected an additional 14 cases of rifampin-resistant TB and initiated treatment in all 14 of these case-patients. Overcrowded living conditions and poor nutrition appeared to be the driving factors behind the high TB incidence in this prison.

KW - Adolescent

KW - Adult

KW - Democratic Republic of the Congo/epidemiology

KW - Demography

KW - Disease Outbreaks

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Mycobacterium tuberculosis/drug effects

KW - Prevalence

KW - Risk Factors

KW - Sputum/microbiology

KW - Tuberculosis/epidemiology

KW - Tuberculosis, Multidrug-Resistant/epidemiology

KW - Young Adult

U2 - 10.3201/eid2411.180769

DO - 10.3201/eid2411.180769

M3 - A1: Web of Science-article

C2 - 30334730

SN - 1080-6040

VL - 24

SP - 2029

EP - 2035

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 11

ER -

Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

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Keywords

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