Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.
|Journal||Diagnostic Microbiology and Infectious Disease|
|Number of pages||5|
|Publication status||Published - 2019|
- Performance evaluation
- Liaison XL