Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test

Y. Van der Beken, D. De Geyter, M. Van Esbroeck

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.

    Original languageEnglish
    JournalDiagnostic Microbiology and Infectious Disease
    Volume95
    Issue number2
    Pages (from-to)144-148
    Number of pages5
    ISSN0732-8893
    DOIs
    Publication statusPublished - 2019

    Keywords

    • Performance evaluation
    • ZIKV
    • Cross-reactivity
    • Diagnosis
    • Liaison XL
    • Diasorin

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