Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test

Y. Van der Beken; D. De Geyter; Marjan Van Esbroeck

doi:10.1016/j.diagmicrobio.2019.05.004

Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test

Y. Van der Beken, D. De Geyter, Marjan Van Esbroeck

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Journal	Diagnostic Microbiology and Infectious Disease
Volume	95
Issue number	2
Pages (from-to)	144-148
Number of pages	5
ISSN	0732-8893
DOIs	https://doi.org/10.1016/j.diagmicrobio.2019.05.004
Publication status	Published - 2019

Keywords

Performance evaluation
ZIKV
Cross-reactivity
Diagnosis
Liaison XL
Diasorin

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10.1016/j.diagmicrobio.2019.05.004

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title = "Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test",

abstract = "Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "Performance evaluation, ZIKV, Cross-reactivity, Diagnosis, Liaison XL, Diasorin",

author = "{Van der Beken}, Y. and {De Geyter}, D. and {Van Esbroeck}, Marjan",

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year = "2019",

doi = "10.1016/j.diagmicrobio.2019.05.004",

language = "English",

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TY - JOUR

T1 - Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test

AU - Van der Beken, Y.

AU - De Geyter, D.

AU - Van Esbroeck, Marjan

N1 - NPP

PY - 2019

Y1 - 2019

N2 - Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.

AB - Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barre syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON (R) XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections. (C) 2019 Elsevier Inc. All rights reserved.

KW - Performance evaluation

KW - ZIKV

KW - Cross-reactivity

KW - Diagnosis

KW - Liaison XL

KW - Diasorin

U2 - 10.1016/j.diagmicrobio.2019.05.004

DO - 10.1016/j.diagmicrobio.2019.05.004

M3 - A1: Web of Science-article

SN - 0732-8893

VL - 95

SP - 144

EP - 148

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -

Performance evaluation of the Diasorin LIAISON (R) XL Zika capture IgM CLIA test

Abstract

Keywords

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