Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

P C A M Buijtels, W W J van de Sande, S Parkinson, P L C Petit, M A B van der Sande, D van Soolingen, H A Verbrugh, A van Belkum

Research output: Contribution to journalA1: Web of Science-article

Abstract

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

Original languageEnglish
JournalInternational Journal of Tuberculosis and Lung Disease
Volume12
Issue number12
Pages (from-to)1485-1488
Number of pages4
ISSN1027-3719
Publication statusPublished - 2008

Keywords

  • Adult
  • Chemokine CCL2/genetics
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Tuberculosis/genetics
  • Zambia

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