Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

P C A M Buijtels; W W J van de Sande; S Parkinson; P L C Petit; M A B van der Sande; D van Soolingen; H A Verbrugh; A van Belkum

Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

P C A M Buijtels
, W W J van de Sande
, S Parkinson
, P L C Petit
, M A B van der Sande
, D van Soolingen
, H A Verbrugh
, A van Belkum

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

Original language	English
Journal	International Journal of Tuberculosis and Lung Disease
Volume	12
Issue number	12
Pages (from-to)	1485-1488
Number of pages	4
ISSN	1027-3719
Publication status	Published - 2008

Keywords

Adult
Chemokine CCL2/genetics
Female
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Single Nucleotide
Tuberculosis/genetics
Zambia

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Buijtels, P. C. A. M., van de Sande, W. W. J., Parkinson, S., Petit, P. L. C., van der Sande, M. A. B., van Soolingen, D., Verbrugh, H. A., & van Belkum, A. (2008). Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia. International Journal of Tuberculosis and Lung Disease, 12(12), 1485-1488. https://www.ingentaconnect.com/content/iuatld/ijtld/2008/00000012/00000012/art00025;jsessionid=3nfsjhmsvio97.x-ic-live-01

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title = "Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia",

abstract = "Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95\%CI 1.3-5.5).",

keywords = "Adult, Chemokine CCL2/genetics, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Tuberculosis/genetics, Zambia",

author = "Buijtels, \{P C A M\} and \{van de Sande\}, \{W W J\} and S Parkinson and Petit, \{P L C\} and \{van der Sande\}, \{M A B\} and \{van Soolingen\}, D and Verbrugh, \{H A\} and \{van Belkum\}, A",

note = "FTX",

year = "2008",

language = "English",

volume = "12",

pages = "1485--1488",

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publisher = "International Union Against Tuberculosis and Lung Disease",

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Buijtels, PCAM, van de Sande, WWJ, Parkinson, S, Petit, PLC, van der Sande, MAB, van Soolingen, D, Verbrugh, HA & van Belkum, A 2008, 'Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia', International Journal of Tuberculosis and Lung Disease, vol. 12, no. 12, pp. 1485-1488. <https://www.ingentaconnect.com/content/iuatld/ijtld/2008/00000012/00000012/art00025;jsessionid=3nfsjhmsvio97.x-ic-live-01>

TY - JOUR

T1 - Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

AU - Buijtels, P C A M

AU - van de Sande, W W J

AU - Parkinson, S

AU - Petit, P L C

AU - van der Sande, M A B

AU - van Soolingen, D

AU - Verbrugh, H A

AU - van Belkum, A

N1 - FTX

PY - 2008

Y1 - 2008

N2 - Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

AB - Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

KW - Adult

KW - Chemokine CCL2/genetics

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Tuberculosis/genetics

KW - Zambia

M3 - A1: Peer-reviewed journal articles

C2 - 19017462

SN - 1027-3719

VL - 12

SP - 1485

EP - 1488

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 12

ER -

Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

Abstract

Keywords

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