Population screening for urine antigens to detect asymptomatic subarachnoid neurocysticercosis: a pilot study in northern Peru

Cysticercosis Working Grp Peru

Research output: Contribution to journalA1: Web of Science-article

Abstract

Subarachnoid neurocysticercosis (SANCC) is a severe and progressive brain infection with Taenia solium. We performed a pilot study of noninvasive screening for SANCC in two endemic villages in northern Peru using a urine antigen screen followed by brain magnetic resonance imaging for participants with elevated levels of antigen. Among the 978 participants screened, we identified eight individuals with SANCC, many of whom were asymptomatic. This represents a minimum prevalence of 0.8% of SANCC, a level higher than expected based on prior studies, and a positive predictive value of 62% for our novel urine screening test. Future studies should confirm whether early detection and management improve clinical outcomes.

Original languageEnglish
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume103
Issue number3
Pages (from-to)1125-1128
Number of pages4
ISSN0002-9637
DOIs
Publication statusPublished - 2020

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Antigens, Helminth/urine
  • Asymptomatic Diseases
  • Brain/diagnostic imaging
  • Child
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neurocysticercosis/diagnostic imaging
  • Peru/epidemiology
  • Pilot Projects
  • Subarachnoid Space/immunology
  • Taenia solium/immunology
  • Taeniasis/diagnostic imaging
  • Young Adult

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