Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis

Chris Kenyon

doi:10.1016/j.ijid.2022.01.022

Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis

Chris Kenyon

Sexually Transmitted Infections

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

BACKGROUND: The reasons underpinning the large differences in the prevalence of resistance to macrolides in Streptococcus pneumoniae are imperfectly understood. We assessed if the volume of macrolides used in food-animals could play a role.

METHODS: Logistic regression was used to assess if the country-level prevalence of pneumococcal macrolide resistance was associated with country-level macrolide consumption in food animals and humans.

RESULTS: In both univariate and multivariate models, macrolide use in food-producing animals was significantly associated with pneumococcal macrolide resistance (coeff. = 339, 95% CI 21 - 658; P = 0.037).

CONCLUSIONS: In vitro and individual-level studies are required to verify or refute the hypothesis that macrolides used in food animals can promote the spread of macrolide resistance in humans.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	116
Pages (from-to)	344-347
Number of pages	4
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2022.01.022
Publication status	Published - 2022

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2022ijid0344Final published version, 362 KBLicence: CC BY-NC-ND

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title = "Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis",

abstract = "BACKGROUND: The reasons underpinning the large differences in the prevalence of resistance to macrolides in Streptococcus pneumoniae are imperfectly understood. We assessed if the volume of macrolides used in food-animals could play a role.METHODS: Logistic regression was used to assess if the country-level prevalence of pneumococcal macrolide resistance was associated with country-level macrolide consumption in food animals and humans.RESULTS: In both univariate and multivariate models, macrolide use in food-producing animals was significantly associated with pneumococcal macrolide resistance (coeff. = 339, 95% CI 21 - 658; P = 0.037).CONCLUSIONS: In vitro and individual-level studies are required to verify or refute the hypothesis that macrolides used in food animals can promote the spread of macrolide resistance in humans.",

author = "Chris Kenyon",

note = "FTX; DOAJ ; Copyright {\textcopyright} 2022. Published by Elsevier Ltd.",

year = "2022",

doi = "10.1016/j.ijid.2022.01.022",

language = "English",

volume = "116",

pages = "344--347",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

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TY - JOUR

T1 - Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis

AU - Kenyon, Chris

PY - 2022

Y1 - 2022

N2 - BACKGROUND: The reasons underpinning the large differences in the prevalence of resistance to macrolides in Streptococcus pneumoniae are imperfectly understood. We assessed if the volume of macrolides used in food-animals could play a role.METHODS: Logistic regression was used to assess if the country-level prevalence of pneumococcal macrolide resistance was associated with country-level macrolide consumption in food animals and humans.RESULTS: In both univariate and multivariate models, macrolide use in food-producing animals was significantly associated with pneumococcal macrolide resistance (coeff. = 339, 95% CI 21 - 658; P = 0.037).CONCLUSIONS: In vitro and individual-level studies are required to verify or refute the hypothesis that macrolides used in food animals can promote the spread of macrolide resistance in humans.

AB - BACKGROUND: The reasons underpinning the large differences in the prevalence of resistance to macrolides in Streptococcus pneumoniae are imperfectly understood. We assessed if the volume of macrolides used in food-animals could play a role.METHODS: Logistic regression was used to assess if the country-level prevalence of pneumococcal macrolide resistance was associated with country-level macrolide consumption in food animals and humans.RESULTS: In both univariate and multivariate models, macrolide use in food-producing animals was significantly associated with pneumococcal macrolide resistance (coeff. = 339, 95% CI 21 - 658; P = 0.037).CONCLUSIONS: In vitro and individual-level studies are required to verify or refute the hypothesis that macrolides used in food animals can promote the spread of macrolide resistance in humans.

U2 - 10.1016/j.ijid.2022.01.022

DO - 10.1016/j.ijid.2022.01.022

M3 - A1: Web of Science-article

C2 - 35038599

SN - 1201-9712

VL - 116

SP - 344

EP - 347

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis

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