Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia: a case-control study

K. Deribe; A. Yami; A. Deribew; N. Mesfin; Robert Colebunders; J.P. Van geertruyden; M. Woldie; T. Maja

doi:10.1177/2325957413500528

Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia: a case-control study

K. Deribe, A. Yami, A. Deribew, N. Mesfin, Robert Colebunders, J.P. Van geertruyden, M. Woldie, T. Maja

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

Abstract

Background:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients. Methods:We conducted an unmatched case-control study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period. Results:Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients. Conclusion:Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.

Original language	English
Journal	Journal of the International Association of Providers of AIDS Care
Volume	14
Issue number	3
Pages (from-to)	269-273
Number of pages	5
ISSN	2325-9574
DOIs	https://doi.org/10.1177/2325957413500528
Publication status	Published - 2015

Keywords

Viral diseases
HIV
AIDS
Co-infections
Bacterial diseases
Tuberculosis
Mycobacterium tuberculosis
Epidemiology
Mortality
Predictors
Gender
Cough
Causes of death
Follow-up
Ethiopia
Africa-East

Access to Document

10.1177/2325957413500528Licence: Unspecified

Cite this

@article{ca9056511f044624b13fcec493d335ca,

title = "Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia: a case-control study",

abstract = "Background:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients. Methods:We conducted an unmatched case-control study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period. Results:Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients. Conclusion:Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.",

keywords = "Viral diseases, HIV, AIDS, Co-infections, Bacterial diseases, Tuberculosis, Mycobacterium tuberculosis, Epidemiology, Mortality, Predictors, Gender, Cough, Causes of death, Follow-up, Ethiopia, Africa-East",

author = "K. Deribe and A. Yami and A. Deribew and N. Mesfin and Robert Colebunders and {Van geertruyden}, J.P. and M. Woldie and T. Maja",

note = "NPP",

year = "2015",

doi = "10.1177/2325957413500528",

language = "English",

volume = "14",

pages = "269--273",

journal = "Journal of the International Association of Providers of AIDS Care",

issn = "2325-9574",

publisher = "Sage Publications",

number = "3",

}

Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia: a case-control study. / Deribe, K.; Yami, A.; Deribew, A. et al.
In: Journal of the International Association of Providers of AIDS Care, Vol. 14, No. 3, 2015, p. 269-273.

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

TY - JOUR

T1 - Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia

T2 - a case-control study

AU - Deribe, K.

AU - Yami, A.

AU - Deribew, A.

AU - Mesfin, N.

AU - Colebunders, Robert

AU - Van geertruyden, J.P.

AU - Woldie, M.

AU - Maja, T.

N1 - NPP

PY - 2015

Y1 - 2015

N2 - Background:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients. Methods:We conducted an unmatched case-control study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period. Results:Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients. Conclusion:Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.

AB - Background:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients. Methods:We conducted an unmatched case-control study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period. Results:Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients. Conclusion:Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.

KW - Viral diseases

KW - HIV

KW - AIDS

KW - Co-infections

KW - Bacterial diseases

KW - Tuberculosis

KW - Mycobacterium tuberculosis

KW - Epidemiology

KW - Mortality

KW - Predictors

KW - Gender

KW - Cough

KW - Causes of death

KW - Follow-up

KW - Ethiopia

KW - Africa-East

U2 - 10.1177/2325957413500528

DO - 10.1177/2325957413500528

M3 - A2: International peer reviewed article (not A1-type)

C2 - 23966102

SN - 2325-9574

VL - 14

SP - 269

EP - 273

JO - Journal of the International Association of Providers of AIDS Care

JF - Journal of the International Association of Providers of AIDS Care

IS - 3

ER -

Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia: a case-control study

Abstract

Keywords

Access to Document

Fingerprint

Cite this