Prevalence and concordance of HPV, HIV, and HSV-2 in heterosexual couples in Kigali, Rwanda

NJ Veldhuijzen, N Dhont, J Vyankandondera, A Gasarabwe, R Busasa, T Crucitti, JH van de Wijgert

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    BACKGROUND: : In the absence of prospectively collected transmission data, the transmission potential of a sexually transmissible infection (STI) can be estimated by its proxy of concordance in sexual partners. Here we report concordance data of 3 viral STIs: human papillomavirus (HPV), HIV, and herpes simplex virus type 2 (HSV-2) among heterosexual couples in Kigali, Rwanda. METHODS: : Cervical and penile HPV typing was performed among 166 community-sampled fertile couples in Kigali, Rwanda (median sampling interval 10 days (interquartile range: 5-36). HIV and HSV-2 serostatus, curable STIs, and sociobehavioral and clinical characteristics were also assessed. RESULTS: : Concordance rates for all 3 viral STIs were higher than expected by chance alone. Positive concordance among couples was 25% for HSV-2, 15.7% for any HPV, 8.4% for high-risk (HR)-HPV, and 6% for HIV. HR-HPV prevalence among women and men was 19.9% and 26.5%, respectively. Partner's HIV status was more strongly associated with HR-HPV detection in men (OR: 8.5; confidence interval: 2.9-24.6) than in women (OR: 1.9; confidence interval 0.5-6.7). CONCLUSION: : More than half of the couples were discordant for HIV, HPV, and/or HSV-2, indicating that prevention strategies directed to infected cases are important to protect their uninfected sexual partners.
    Original languageEnglish
    JournalSexually Transmitted Diseases
    Volume39
    Issue number2
    Pages (from-to)128-135
    ISSN0148-5717
    DOIs
    Publication statusPublished - 2012

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • HSV-2
    • Herpes simplex virus type 2
    • Cervix neoplasms
    • Cancer
    • Epidemiology
    • Prevalence
    • Heterosexual
    • Couples
    • Men
    • Women
    • Discordance
    • Disease transmission-sexual
    • Social aspects
    • Risk behavior
    • Genotyping
    • Rwanda
    • Africa-Central

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