Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda

J Vandepitte, E Muller, J Bukenya, S Nakubulwa, N Kyakuwa, A Buvé, H Weiss, R Hayes, H Grosskurth

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Background. The importance of Mycoplasma genitalium in human immunodeficiency virus (HIV)-burdened sub-Saharan Africa is relatively unknown. We assessed the prevalence and explored determinants of this emerging sexually transmitted infection (STI) in high-risk women in Uganda.Methods. Endocervical swabs from 1025 female sex workers in Kampala were tested for Mycoplasma genitalium using a commercial Real-TM polymerase chain reaction assay. Factors associated with prevalent Mycoplasma genitalium, including sociodemographics, reproductive history, risk behavior, and HIV and other STIs, were examined using multivariable logistic regression.Results. The prevalence of Mycoplasma genitalium was 14% and higher in HIV-positive women than in HIV-negative women (adjusted odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12-2.41). Mycoplasma genitalium infection was less prevalent in older women (adjusted OR, 0.61; 95% CI, .41-.90 for women ages 25-34 years vs <25 years; adjusted OR, 0.32; 95% CI, .15-.71 for women >/=35 years vs those <25 years) and in those who had been pregnant but never had a live birth (adjusted OR, 2.25; 95% CI, 1.04-4.88). Mycoplasma genitalium was associated with Neisseria gonorrhoeae (adjusted OR, 1.84; 95% CI, 1.13-2.98) and with Candida infection (adjusted OR, 0.41; 95% CI, .18-.91), and there was some evidence of association with Trichomonas vaginalis (adjusted OR, 1.56; 95% CI, 1.00-2.44).Conclusions. The relatively high prevalence of Mycoplasma genitalium and its association with prevalent HIV urgently calls for further research to explore the potential role this emerging STI plays in the acquisition and transmission of HIV infection.
    Original languageEnglish
    JournalJournal of Infectious Diseases
    Volume205
    Issue number2
    Pages (from-to)289-296
    Number of pages8
    ISSN0022-1899
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Sexually transmitted diseases
    • STD
    • Mycoplasma genitalium
    • Prevalence
    • Women
    • Prostitutes
    • Determinants
    • Risk factors
    • Sociodemographic aspects
    • Reproductive health
    • Pregnancy
    • Risk behavior
    • Co-infections
    • Viral diseases
    • HIV
    • AIDS
    • Age
    • Associations
    • Neisseria gonorrhoeae
    • Candida
    • Trichomonas vaginalis
    • Uganda
    • Africa-East

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