Prevalence case-control study of epilepsy in three Burkina Faso villages

P. Nitiéma, H. Carabin, S. Hounton, N. Praet, L.D. Cowan, R. Ganaba, C. Kompaore, Z. Tarnagda, P. Dorny, A. Millogo

Research output: Contribution to journalA1: Web of Science-article

Abstract

PURPOSE: To estimate the association between the prevalence of epilepsy and potential risk factors in three Burkina Faso villages. METHODS: Three villages were selected based on local reports of high numbers of epilepsy cases and pig-rearing practices. One person aged 7 or older was selected at random from all households of selected concessions for epilepsy screening and blood sampling. Epilepsy was confirmed by a physician using the ILAE definition. The cross-sectional associations between epilepsy and selected factors and seroresponse to the antigens of Taenia solium were estimated using a Bayesian hierarchical logistic regression. Prevalence odds ratios (POR) and their 95% Bayesian Credible Intervals (95% BCI) were estimated. RESULTS: Of 888 individuals interviewed, 39 of 70 screened positive were confirmed to have epilepsy for a lifetime prevalence of 4.5% (95% CI: 3.3; 6.0). The prevalence of epilepsy was associated with a positive reaction to cysticercosis Ag-ELISA serology (POR = 3.1, 95% BCI = 1.0; 8.3), past pork consumption (POR = 9.7, 95% BCI = 2.5; 37.9), and being salaried or a trader compared to a farmer or housewife (POR = 2.9, 95% BCI = 1.2; 6.4). DISCUSSION: Several factors were associated with prevalent epilepsy, with Ag-ELISA suggesting the presence of neurocysticercosis. The association between epilepsy and some occupations may reflect differences in local attitudes toward epilepsy and should be further explored.
Original languageEnglish
JournalActa Neurologica Scandinavica
Volume126
Issue number4
Pages (from-to)270-278
Number of pages9
ISSN0001-6314
DOIs
Publication statusPublished - 2012

Keywords

  • Helminthic diseases
  • Zoonoses
  • Taenia solium
  • Epilepsy
  • Pigs
  • Prevalence
  • Associations
  • Risk factors
  • Estimation
  • Ag-ELISA
  • Meat
  • Consumption
  • Farmers
  • Age distribution
  • Burkina Faso
  • Africa-West

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