Prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa

Wim van der Hoek; Ramu Sarge-Njie; Tineke Herremans; Thomas Chisnall; Joseph Okebe; Eniyou Oriero; Bart Versteeg; Bart Goossens; Marianne van der Sande; Beate Kampmann; Davis Nwakanma

doi:10.1111/tmi.12116

Prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa

Wim van der Hoek, Ramu Sarge-Njie, Tineke Herremans, Thomas Chisnall, Joseph Okebe, Eniyou Oriero, Bart Versteeg, Bart Goossens, Marianne van der Sande, Beate Kampmann, Davis Nwakanma

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Abstract

OBJECTIVE: To estimate the prevalence of antibodies against Coxiella burnetii (Q fever) among children in eight villages in The Gambia, West Africa.

METHODS: Sera of 796 children aged 1-15 years were tested for presence of antibodies against phase II of C. burnetii by ELISA.

RESULTS: IgG and/or IgM phase II antibodies against C. burnetii were detectable in 8.3% (66/796) of all serum samples analysed with significant differences in seroprevalence between villages. Highest prevalence was found in the age group 1-4 years.

CONCLUSIONS: Exposure to C. burnetii is considerable in the early years of life in The Gambia, and further studies are warranted to estimate the role of Q fever in acute febrile illness in The Gambia and elsewhere in Africa.

Original language	English
Journal	Tropical Medicine and International Health
Volume	18
Issue number	7
Pages (from-to)	850-853
Number of pages	4
ISSN	1360-2276
DOIs	https://doi.org/10.1111/tmi.12116
Publication status	Published - 2013

Keywords

Adolescent
Age Factors
Antibodies/blood
Antibodies, Bacterial/blood
Child
Child, Preschool
Coxiella burnetii/immunology
Enzyme-Linked Immunosorbent Assay
Female
Gambia/epidemiology
Humans
Immunoglobulin G/blood
Immunoglobulin M/blood
Male
Q Fever/blood
Seroepidemiologic Studies

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2013tmih0850Final published version, 51.5 KBLicence: Unspecified

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title = "Prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa",

abstract = "OBJECTIVE: To estimate the prevalence of antibodies against Coxiella burnetii (Q fever) among children in eight villages in The Gambia, West Africa.METHODS: Sera of 796 children aged 1-15 years were tested for presence of antibodies against phase II of C. burnetii by ELISA.RESULTS: IgG and/or IgM phase II antibodies against C. burnetii were detectable in 8.3% (66/796) of all serum samples analysed with significant differences in seroprevalence between villages. Highest prevalence was found in the age group 1-4 years.CONCLUSIONS: Exposure to C. burnetii is considerable in the early years of life in The Gambia, and further studies are warranted to estimate the role of Q fever in acute febrile illness in The Gambia and elsewhere in Africa.",

keywords = "Adolescent, Age Factors, Antibodies/blood, Antibodies, Bacterial/blood, Child, Child, Preschool, Coxiella burnetii/immunology, Enzyme-Linked Immunosorbent Assay, Female, Gambia/epidemiology, Humans, Immunoglobulin G/blood, Immunoglobulin M/blood, Male, Q Fever/blood, Seroepidemiologic Studies",

author = "{van der Hoek}, Wim and Ramu Sarge-Njie and Tineke Herremans and Thomas Chisnall and Joseph Okebe and Eniyou Oriero and Bart Versteeg and Bart Goossens and {van der Sande}, Marianne and Beate Kampmann and Davis Nwakanma",

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year = "2013",

doi = "10.1111/tmi.12116",

language = "English",

volume = "18",

pages = "850--853",

journal = "Tropical Medicine and International Health",

issn = "1360-2276",

publisher = "John Wiley & Sons",

number = "7",

}

TY - JOUR

T1 - Prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa

AU - van der Hoek, Wim

AU - Sarge-Njie, Ramu

AU - Herremans, Tineke

AU - Chisnall, Thomas

AU - Okebe, Joseph

AU - Oriero, Eniyou

AU - Versteeg, Bart

AU - Goossens, Bart

AU - van der Sande, Marianne

AU - Kampmann, Beate

AU - Nwakanma, Davis

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: To estimate the prevalence of antibodies against Coxiella burnetii (Q fever) among children in eight villages in The Gambia, West Africa.METHODS: Sera of 796 children aged 1-15 years were tested for presence of antibodies against phase II of C. burnetii by ELISA.RESULTS: IgG and/or IgM phase II antibodies against C. burnetii were detectable in 8.3% (66/796) of all serum samples analysed with significant differences in seroprevalence between villages. Highest prevalence was found in the age group 1-4 years.CONCLUSIONS: Exposure to C. burnetii is considerable in the early years of life in The Gambia, and further studies are warranted to estimate the role of Q fever in acute febrile illness in The Gambia and elsewhere in Africa.

AB - OBJECTIVE: To estimate the prevalence of antibodies against Coxiella burnetii (Q fever) among children in eight villages in The Gambia, West Africa.METHODS: Sera of 796 children aged 1-15 years were tested for presence of antibodies against phase II of C. burnetii by ELISA.RESULTS: IgG and/or IgM phase II antibodies against C. burnetii were detectable in 8.3% (66/796) of all serum samples analysed with significant differences in seroprevalence between villages. Highest prevalence was found in the age group 1-4 years.CONCLUSIONS: Exposure to C. burnetii is considerable in the early years of life in The Gambia, and further studies are warranted to estimate the role of Q fever in acute febrile illness in The Gambia and elsewhere in Africa.

KW - Adolescent

KW - Age Factors

KW - Antibodies/blood

KW - Antibodies, Bacterial/blood

KW - Child

KW - Child, Preschool

KW - Coxiella burnetii/immunology

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Gambia/epidemiology

KW - Humans

KW - Immunoglobulin G/blood

KW - Immunoglobulin M/blood

KW - Male

KW - Q Fever/blood

KW - Seroepidemiologic Studies

U2 - 10.1111/tmi.12116

DO - 10.1111/tmi.12116

M3 - A1: Web of Science-article

C2 - 23600611

SN - 1360-2276

VL - 18

SP - 850

EP - 853

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 7

ER -

Prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa

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Keywords

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