Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F Brun-Vézinet, C Rouzioux, L Montagnier, S Chamaret, J Gruest, F Barré-Sinoussi, D Geroldi, JC Chermann, J McCormick, S Mitchell, P Piot, H Taelman, BM Kapita, W Odio, N Mbendi, P Mazebo, K Kayembe, C Bridts, J Desmyter, FM FeinsodTC Quinn

Research output: Contribution to journalA2: International peer reviewed article (not A1-type)

Abstract

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire
Original languageEnglish
JournalScience
Volume226
Pages (from-to)453-456
ISSN0036-8075
Publication statusPublished - 1984

Keywords

  • B780-tropical-medicine
  • Viral diseases
  • AIDS
  • Immunology
  • Antibodies
  • Lymphatic diseases
  • Microbiology
  • Retroviruses
  • ELISA
  • Helper cells
  • Cytology
  • Immunoassay
  • Suppressor cells
  • Congo-Kinshasa
  • Africa-Central

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