Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F Brun-Vézinet; C Rouzioux; L Montagnier; S Chamaret; J Gruest; F Barré-Sinoussi; D Geroldi; JC Chermann; J McCormick; S Mitchell; P Piot; H Taelman; BM Kapita; W Odio; N Mbendi; P Mazebo; K Kayembe; C Bridts; J Desmyter; FM Feinsod; TC Quinn

Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F Brun-Vézinet
, C Rouzioux
, L Montagnier
, S Chamaret
, J Gruest
, F Barré-Sinoussi
, D Geroldi
, JC Chermann
, J McCormick
, S Mitchell
, P Piot
, H Taelman
, BM Kapita
, W Odio
, N Mbendi
, P Mazebo
, K Kayembe
, C Bridts
, J Desmyter
, FM Feinsod

TC Quinn

Institute of Tropical Medicine

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

Abstract

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire

Original language	English
Journal	Science
Volume	226
Pages (from-to)	453-456
ISSN	0036-8075
Publication status	Published - 1984

Keywords

B780-tropical-medicine
Viral diseases
AIDS
Immunology
Antibodies
Lymphatic diseases
Microbiology
Retroviruses
ELISA
Helper cells
Cytology
Immunoassay
Suppressor cells
Congo-Kinshasa
Africa-Central

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Cite this

Brun-Vézinet, F., Rouzioux, C., Montagnier, L., Chamaret, S., Gruest, J., Barré-Sinoussi, F., Geroldi, D., Chermann, JC., McCormick, J., Mitchell, S., Piot, P., Taelman, H., Kapita, BM., Odio, W., Mbendi, N., Mazebo, P., Kayembe, K., Bridts, C., Desmyter, J., ... Quinn, TC. (1984). Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. Science, 226, 453-456. http://lib.itg.be/pdf/itg/1984/1984scie0453.pdf

@article{5d8fcd0c6ad047ff8cb32ee1840e22c0,

title = "Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS",

abstract = "The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire",

keywords = "B780-tropical-medicine, Viral diseases, AIDS, Immunology, Antibodies, Lymphatic diseases, Microbiology, Retroviruses, ELISA, Helper cells, Cytology, Immunoassay, Suppressor cells, Congo-Kinshasa, Africa-Central",

author = "F Brun-V{\'e}zinet and C Rouzioux and L Montagnier and S Chamaret and J Gruest and F Barr{\'e}-Sinoussi and D Geroldi and JC Chermann and J McCormick and S Mitchell and P Piot and H Taelman and BM Kapita and W Odio and N Mbendi and P Mazebo and K Kayembe and C Bridts and J Desmyter and FM Feinsod and TC Quinn",

year = "1984",

language = "English",

volume = "226",

pages = "453--456",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

}

Brun-Vézinet, F, Rouzioux, C, Montagnier, L, Chamaret, S, Gruest, J, Barré-Sinoussi, F, Geroldi, D, Chermann, JC, McCormick, J, Mitchell, S, Piot, P, Taelman, H, Kapita, BM, Odio, W, Mbendi, N, Mazebo, P, Kayembe, K, Bridts, C, Desmyter, J, Feinsod, FM & Quinn, TC 1984, 'Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS', Science, vol. 226, pp. 453-456. <http://lib.itg.be/pdf/itg/1984/1984scie0453.pdf>

TY - JOUR

T1 - Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

AU - Brun-Vézinet, F

AU - Rouzioux, C

AU - Montagnier, L

AU - Chamaret, S

AU - Gruest, J

AU - Barré-Sinoussi, F

AU - Geroldi, D

AU - Chermann, JC

AU - McCormick, J

AU - Mitchell, S

AU - Piot, P

AU - Taelman, H

AU - Kapita, BM

AU - Odio, W

AU - Mbendi, N

AU - Mazebo, P

AU - Kayembe, K

AU - Bridts, C

AU - Desmyter, J

AU - Feinsod, FM

AU - Quinn, TC

PY - 1984

Y1 - 1984

N2 - The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire

AB - The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire

KW - B780-tropical-medicine

KW - Viral diseases

KW - AIDS

KW - Immunology

KW - Antibodies

KW - Lymphatic diseases

KW - Microbiology

KW - Retroviruses

KW - ELISA

KW - Helper cells

KW - Cytology

KW - Immunoassay

KW - Suppressor cells

KW - Congo-Kinshasa

KW - Africa-Central

M3 - A2: International peer reviewed article (not A1-type)

SN - 0036-8075

VL - 226

SP - 453

EP - 456

JO - Science

JF - Science

ER -

Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

Abstract

Keywords

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