Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

D Mumba; E Bohorquez; J Messina; V Kande; SM Taylor; AK Tshefu; J Muwonga; MM Kashamuka; M Emch; R Tidwell; P Büscher; SR Meshnick

doi:10.1371/journal.pntd.0001246

Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

D Mumba, E Bohorquez, J Messina, V Kande, SM Taylor, AK Tshefu, J Muwonga, MM Kashamuka, M Emch, R Tidwell, P Büscher, SR Meshnick

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Abstract

Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.

Original language	English
Journal	PLoS Neglected Tropical Diseases
Volume	5
Issue number	8
Pages (from-to)	e1246
Number of pages	5
ISSN	1935-2727
DOIs	https://doi.org/10.1371/journal.pntd.0001246
Publication status	Published - 2011

Keywords

B780-tropical-medicine
Protozoal diseases
Trypanosomiasis-African
Sleeping sickness
Trypanosoma brucei gambiense
Trypanosoma brucei rhodesiense
Vectors
Tsetse flies
Glossina
Prevalence
Disease burden
Surveillance
ELISA
Trypanolysis
PCR
DNA sequence analysis
Congo-Kinshasa
Africa-Central

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2011pntde1246

http://lib.itg.be/pdf/itg/2011/2011pntde1246.pdf

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title = "Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo",

abstract = "Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.",

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AU - Mumba, D

AU - Bohorquez, E

AU - Messina, J

AU - Kande, V

AU - Taylor, SM

AU - Tshefu, AK

AU - Muwonga, J

AU - Kashamuka, MM

AU - Emch, M

AU - Tidwell, R

AU - Büscher, P

AU - Meshnick, SR

N1 - FTX; ITG-P11A; PARAS; U-SEROL; JIF; E-only; DOI; PDF; Abstract; DSPACE

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N2 - Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.

AB - Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.

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KW - Trypanosomiasis-African

KW - Sleeping sickness

KW - Trypanosoma brucei gambiense

KW - Trypanosoma brucei rhodesiense

KW - Vectors

KW - Tsetse flies

KW - Glossina

KW - Prevalence

KW - Disease burden

KW - Surveillance

KW - ELISA

KW - Trypanolysis

KW - PCR

KW - DNA sequence analysis

KW - Congo-Kinshasa

KW - Africa-Central

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SN - 1935-2727

VL - 5

SP - e1246

JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

IS - 8

ER -

Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

Abstract

Keywords

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