Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

D Mumba, E Bohorquez, J Messina, V Kande, SM Taylor, AK Tshefu, J Muwonga, MM Kashamuka, M Emch, R Tidwell, P Büscher, SR Meshnick

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    Abstract

    Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.
    Original languageEnglish
    JournalPLoS Neglected Tropical Diseases
    Volume5
    Issue number8
    Pages (from-to)e1246
    Number of pages5
    ISSN1935-2727
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Trypanosomiasis-African
    • Sleeping sickness
    • Trypanosoma brucei gambiense
    • Trypanosoma brucei rhodesiense
    • Vectors
    • Tsetse flies
    • Glossina
    • Prevalence
    • Disease burden
    • Surveillance
    • ELISA
    • Trypanolysis
    • PCR
    • DNA sequence analysis
    • Congo-Kinshasa
    • Africa-Central

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