Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption

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We hypothesized that the large global variations in the prevalence of macrolide resistance in Treponema pallidum are related to differences in population-level macrolide consumption. The hypothesis was tested by, at a country-level, regressing the peak prevalence of macrolide resistance against the national macrolide consumption in the year prior to this, controlling for the year of the resistance prevalence estimate. A strong association was found between the per capita consumption of macrolides and macrolide resistance (coefficient 0.7, 95 % confidence interval 0.2-0.12, P=0.009).

Original languageEnglish
JournalJournal of Medical Microbiology
Issue number2
Pages (from-to)119-123
Number of pages5
Publication statusPublished - 2019


  • Drug Resistance, Bacterial
  • Global Health
  • Humans
  • Linear Models
  • Macrolides/administration & dosage
  • Treponema pallidum/drug effects


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