Abstract
We hypothesized that the large global variations in the prevalence of macrolide resistance in Treponema pallidum are related to differences in population-level macrolide consumption. The hypothesis was tested by, at a country-level, regressing the peak prevalence of macrolide resistance against the national macrolide consumption in the year prior to this, controlling for the year of the resistance prevalence estimate. A strong association was found between the per capita consumption of macrolides and macrolide resistance (coefficient 0.7, 95 % confidence interval 0.2-0.12, P=0.009).
| Original language | English |
|---|---|
| Journal | Journal of Medical Microbiology |
| Volume | 68 |
| Issue number | 2 |
| Pages (from-to) | 119-123 |
| Number of pages | 5 |
| ISSN | 0022-2615 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Drug Resistance, Bacterial
- Global Health
- Humans
- Linear Models
- Macrolides/administration & dosage
- Treponema pallidum/drug effects