Prevalence of tuberculosis in adolescents, western Kenya: implications for control programs

Videlis Nduba; Anna H Van't Hoog; Ellen Mitchell; Peter Onyango; Kayla Laserson; Martien Borgdorff

doi:10.1016/j.ijid.2015.03.008

Prevalence of tuberculosis in adolescents, western Kenya: implications for control programs

Videlis Nduba, Anna H Van't Hoog, Ellen Mitchell, Peter Onyango, Kayla Laserson, Martien Borgdorff

Mycobacterial Diseases and Neglected Tropical Diseases

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

OBJECTIVE: The aim of this study was to determine the prevalence of tuberculosis (TB) in adolescents in western Kenya.

METHODS: A cohort study of 5004 adolescents aged 12-18 years was conducted. Adolescents were screened for prevalent TB using clinical criteria, history of TB contact, and a Mantoux test. Cases of suspected TB were investigated through two sputum examinations (microscopy and liquid culture) and chest radiography.

RESULTS: Out of 5004 adolescents enrolled, 1960 (39.2%) were identified with suspected TB, including 1544 with a positive Mantoux (prevalence 1544/4808, 32.1%), 515 with symptoms suggestive of TB (10.3%), and 144 (2.9%) with household TB contact. Sixteen culture-confirmed (definite) and 18 probable pulmonary TB (PTB) cases were identified, reflecting a prevalence estimate of 3.2/1000 (definite) and 6.8/1000 all PTB, respectively. Only one smear-positive case was detected. The case notification rate among 12-18-year-old adolescents for all TB was 101/100000, yielding a patient diagnostic rate of 0.13 (95% confidence interval 0.03-3.7) cases detected per person-year for all TB.

CONCLUSION: The prevalence of PTB among adolescents is high, with the majority of cases not detected routinely. Innovative active case finding including the wider use of Xpert MTB/RIF is needed to detect smear-negative TB among adolescents.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	35
Pages (from-to)	11-7
Number of pages	7
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2015.03.008
Publication status	Published - 2015

Keywords

Adolescent
Child
Cohort Studies
Cross-Sectional Studies
Female
Humans
Infection Control
Kenya/epidemiology
Male
Prevalence
Tuberculosis, Pulmonary/diagnosis

Access to Document

10.1016/j.ijid.2015.03.008

Cite this

@article{91ad7f06b07f4d65bc51232557bcdd03,

title = "Prevalence of tuberculosis in adolescents, western Kenya: implications for control programs",

abstract = "OBJECTIVE: The aim of this study was to determine the prevalence of tuberculosis (TB) in adolescents in western Kenya.METHODS: A cohort study of 5004 adolescents aged 12-18 years was conducted. Adolescents were screened for prevalent TB using clinical criteria, history of TB contact, and a Mantoux test. Cases of suspected TB were investigated through two sputum examinations (microscopy and liquid culture) and chest radiography.RESULTS: Out of 5004 adolescents enrolled, 1960 (39.2%) were identified with suspected TB, including 1544 with a positive Mantoux (prevalence 1544/4808, 32.1%), 515 with symptoms suggestive of TB (10.3%), and 144 (2.9%) with household TB contact. Sixteen culture-confirmed (definite) and 18 probable pulmonary TB (PTB) cases were identified, reflecting a prevalence estimate of 3.2/1000 (definite) and 6.8/1000 all PTB, respectively. Only one smear-positive case was detected. The case notification rate among 12-18-year-old adolescents for all TB was 101/100000, yielding a patient diagnostic rate of 0.13 (95% confidence interval 0.03-3.7) cases detected per person-year for all TB.CONCLUSION: The prevalence of PTB among adolescents is high, with the majority of cases not detected routinely. Innovative active case finding including the wider use of Xpert MTB/RIF is needed to detect smear-negative TB among adolescents.",

keywords = "Adolescent, Child, Cohort Studies, Cross-Sectional Studies, Female, Humans, Infection Control, Kenya/epidemiology, Male, Prevalence, Tuberculosis, Pulmonary/diagnosis",

author = "Videlis Nduba and Hoog, {Anna H Van't} and Ellen Mitchell and Peter Onyango and Kayla Laserson and Martien Borgdorff",

year = "2015",

doi = "10.1016/j.ijid.2015.03.008",

language = "English",

volume = "35",

pages = "11--7",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

TY - JOUR

T1 - Prevalence of tuberculosis in adolescents, western Kenya: implications for control programs

AU - Nduba, Videlis

AU - Hoog, Anna H Van't

AU - Mitchell, Ellen

AU - Onyango, Peter

AU - Laserson, Kayla

AU - Borgdorff, Martien

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: The aim of this study was to determine the prevalence of tuberculosis (TB) in adolescents in western Kenya.METHODS: A cohort study of 5004 adolescents aged 12-18 years was conducted. Adolescents were screened for prevalent TB using clinical criteria, history of TB contact, and a Mantoux test. Cases of suspected TB were investigated through two sputum examinations (microscopy and liquid culture) and chest radiography.RESULTS: Out of 5004 adolescents enrolled, 1960 (39.2%) were identified with suspected TB, including 1544 with a positive Mantoux (prevalence 1544/4808, 32.1%), 515 with symptoms suggestive of TB (10.3%), and 144 (2.9%) with household TB contact. Sixteen culture-confirmed (definite) and 18 probable pulmonary TB (PTB) cases were identified, reflecting a prevalence estimate of 3.2/1000 (definite) and 6.8/1000 all PTB, respectively. Only one smear-positive case was detected. The case notification rate among 12-18-year-old adolescents for all TB was 101/100000, yielding a patient diagnostic rate of 0.13 (95% confidence interval 0.03-3.7) cases detected per person-year for all TB.CONCLUSION: The prevalence of PTB among adolescents is high, with the majority of cases not detected routinely. Innovative active case finding including the wider use of Xpert MTB/RIF is needed to detect smear-negative TB among adolescents.

AB - OBJECTIVE: The aim of this study was to determine the prevalence of tuberculosis (TB) in adolescents in western Kenya.METHODS: A cohort study of 5004 adolescents aged 12-18 years was conducted. Adolescents were screened for prevalent TB using clinical criteria, history of TB contact, and a Mantoux test. Cases of suspected TB were investigated through two sputum examinations (microscopy and liquid culture) and chest radiography.RESULTS: Out of 5004 adolescents enrolled, 1960 (39.2%) were identified with suspected TB, including 1544 with a positive Mantoux (prevalence 1544/4808, 32.1%), 515 with symptoms suggestive of TB (10.3%), and 144 (2.9%) with household TB contact. Sixteen culture-confirmed (definite) and 18 probable pulmonary TB (PTB) cases were identified, reflecting a prevalence estimate of 3.2/1000 (definite) and 6.8/1000 all PTB, respectively. Only one smear-positive case was detected. The case notification rate among 12-18-year-old adolescents for all TB was 101/100000, yielding a patient diagnostic rate of 0.13 (95% confidence interval 0.03-3.7) cases detected per person-year for all TB.CONCLUSION: The prevalence of PTB among adolescents is high, with the majority of cases not detected routinely. Innovative active case finding including the wider use of Xpert MTB/RIF is needed to detect smear-negative TB among adolescents.

KW - Adolescent

KW - Child

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Infection Control

KW - Kenya/epidemiology

KW - Male

KW - Prevalence

KW - Tuberculosis, Pulmonary/diagnosis

U2 - 10.1016/j.ijid.2015.03.008

DO - 10.1016/j.ijid.2015.03.008

M3 - A1: Web of Science-article

C2 - 25770911

SN - 1201-9712

VL - 35

SP - 11

EP - 17

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Prevalence of tuberculosis in adolescents, western Kenya: implications for control programs

Abstract

Keywords

Access to Document

Fingerprint

Cite this