Prospects and pitfalls: next-generation tools to control mosquito-transmitted disease

E P Caragata, S Dong, Y Dong, Maria Luisa Simões, C V Tikhe, G Dimopoulos

    Research output: Contribution to journalReviewpeer-review


    Mosquito-transmitted diseases, including malaria and dengue, are a major threat to human health around the globe, affecting millions each year. A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens. Many of these new approaches have been built on recent advances in CRISPR/Cas9-based genome editing. These initiatives have driven the development of pathogen-resistant lines, new genetics-based sexing methods, and new methods of driving desirable genetic traits into mosquito populations. Many other emerging tools involve microorganisms, including two strategies involving Wolbachia that are achieving great success in the field. At the same time, other mosquito-associated bacteria, fungi, and even viruses represent untapped sources of new mosquitocidal or antipathogen compounds. Although there are still hurdles to be overcome, the prospect that such approaches will reduce the impact of these diseases is highly encouraging.

    Original languageEnglish
    JournalAnnual Review of Microbiology
    Pages (from-to)455-475
    Number of pages21
    Publication statusPublished - 2020


    • Animals
    • Biological Control Agents
    • Communicable Disease Control
    • Communicable Diseases/parasitology
    • Culicidae/genetics
    • Humans
    • Infertility
    • Malaria
    • Mosquito Control/methods
    • Wolbachia/genetics


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