Public health measures to control the spread of antimicrobial resistance in Neisseria gonorrhoeae in men who have sex with men

M Xiridou, L C Soetens, F D H Koedijk, M A B van der Sande, J Wallinga

Research output: Contribution to journalA1: Web of Science-article

1 Downloads (Pure)

Abstract

Gonorrhoea is one of the most common sexually transmitted infections. The control of gonorrhoea is extremely challenging because of the repeated development of resistance to the antibiotics used for its treatment. We explored different strategies to control the spread of antimicrobial resistance and prevent increases in gonorrhoea prevalence. We used a mathematical model that describes gonorrhoea transmission among men who have sex with men and distinguishes gonorrhoea strains sensitive or resistant to three antibiotics. We investigated the impact of combination therapy, switching first-line antibiotics according to resistance thresholds, and other control efforts (reduced sexual risk behaviour, increased treatment rate). Combination therapy can delay the spread of resistance better than using the 5% resistance threshold. Increased treatment rates, expected to enhance gonorrhoea control, may reduce gonorrhoea prevalence only in the short term, but could lead to more resistance and higher prevalence in the long term. Re-treatment of resistant cases with alternative antibiotics can substantially delay the spread of resistance. In conclusion, combination therapy and re-treatment of resistant cases with alternative antibiotics could be the most effective strategies to prevent increases in gonorrhoea prevalence due to antimicrobial resistance.

Original languageEnglish
JournalEpidemiology and Infection
Volume143
Issue number8
Pages (from-to)1575-84
Number of pages10
ISSN0950-2688
DOIs
Publication statusPublished - 2015

Keywords

  • Anti-Bacterial Agents/therapeutic use
  • Communicable Disease Control
  • Drug Resistance, Bacterial
  • Drug Substitution
  • Drug Therapy, Combination
  • Gonorrhea/drug therapy
  • Homosexuality, Male
  • Humans
  • Male
  • Models, Theoretical
  • Neisseria gonorrhoeae
  • Public Health
  • Risk-Taking

Fingerprint

Dive into the research topics of 'Public health measures to control the spread of antimicrobial resistance in <i>Neisseria gonorrhoeae</i> in men who have sex with men'. Together they form a unique fingerprint.

Cite this