TY - JOUR
T1 - Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group
AU - APMEN Vivax Working Group
AU - Thriemer, Kamala
AU - Bobogare, Albino
AU - Ley, Benedikt
AU - Gudo, Clarice Samo
AU - Alam, Mohammad Shafiul
AU - Anstey, Nick M.
AU - Ashley, Elizabeth
AU - Baird, J. Kevin
AU - Gryseels, Charlotte
AU - Jambert, Elodie
AU - Lacerda, Marcus
AU - Laihad, Ferdinand
AU - Marfurt, Jutta
AU - Pasaribu, Ayodhia Pitaloka
AU - Poespoprodjo, Jeanne Rini
AU - Sutanto, Inge
AU - Taylor, Walter R.
AU - van den Boogaard, Christel
AU - Battle, Katherine E.
AU - Dysoley, Lek
AU - Ghimire, Prakash
AU - Hawley, Bill
AU - Hwang, Jimee
AU - Khan, Wasif Ali
AU - Mudin, Rose Nani Binti
AU - Sumiwi, Maria Endang
AU - Ahmed, Rukhsana
AU - Aktaruzzaman, M. M.
AU - Awasthi, Kiran Raj
AU - Bardaji, Azucena
AU - Bell, David
AU - Boaz, Leonard
AU - Burdam, Faustina Helen
AU - Chandramohan, Daniel
AU - Cheng, Qin
AU - Chindawongsa, Keobouphaphone
AU - Culpepper, Janice
AU - Das, Santasabuj
AU - Deray, Raffy
AU - Desai, Meghna
AU - Domingo, Gonzalo
AU - Wang Duoquan, null
AU - Duparc, Stephan
AU - Floranita, Rustini
AU - Gerth-Guyette, Emily
AU - Howes, Rosalind E.
AU - Hugo, Cecilia
AU - Jagoe, George
AU - Sariwati, Elvieda
AU - Jhora, Sanya Tahmina
N1 - FTX ; DOAJ
PY - 2018
Y1 - 2018
N2 - The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.
AB - The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.
KW - Vivax malaria
KW - Plasmodium vivax
KW - Adherence
KW - Effectiveness
KW - Efficacy
KW - Radical cure
KW - Primaquine
KW - APMEN
KW - PLASMODIUM-VIVAX
KW - PERUVIAN AMAZON
KW - MEDICATION
KW - METHEMOGLOBINEMIA
KW - THERAPY
KW - MALARIA
KW - PLASMA
U2 - 10.1186/s12936-018-2380-8
DO - 10.1186/s12936-018-2380-8
M3 - A1: Web of Science-article
SN - 1475-2875
VL - 17
JO - Malaria Journal
JF - Malaria Journal
M1 - 241
ER -