Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella.

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Abstract

Neisseria gonorrhoeae is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in N. gonorrhoeae is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for N. gonorrhoeae infection. We tested the effectiveness of ramoplanin in vitro against 14 World Health Organization (WHO) reference strains of N. gonorrhoeae and found that it was active against all 14 strains tested. Furthermore, in a Galleria mellonella infection model of N. gonorrhoeae WHO P, we demonstrated that ramoplanin was active in vivo without any evidence of toxicity. This suggests that ramoplanin might be a new promising antibiotic treatment for gonorrhoea.

Original languageEnglish
JournalJournal of Medical Microbiology
Volume73
Issue number1
ISSN0022-2615
DOIs
Publication statusPublished - 2024

Keywords

  • Humans
  • Gonorrhea/drug therapy
  • Drug Resistance, Bacterial
  • Anti-Bacterial Agents/pharmacology
  • Depsipeptides/pharmacology
  • Neisseria gonorrhoeae
  • Microbial Sensitivity Tests

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