Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Joseph Okebe, Joan Muela Ribera, Julie Balen, Fatou Jaiteh, Yoriko Masunaga, Davis Nwakanma, John Bradley, Shunmay Yeung, Koen Peeters Grietens, Umberto D'Alessandro

Research output: Contribution to journalA1: Web of Science-article

Abstract

Background: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.

Methods/design: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.

Discussion: Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.

Original languageEnglish
Article number126
JournalTrials
Volume19
Number of pages8
ISSN1745-6215
DOIs
Publication statusPublished - 2018

Keywords

  • Reactive case treatment
  • Community
  • Plasmodium falciparum
  • Formative research
  • Prevalence
  • OPERATIONAL CHALLENGES
  • PLASMODIUM-FALCIPARUM
  • GAMBIA
  • ELIMINATION
  • RESISTANCE

Cite this