TY - JOUR
T1 - Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy
AU - Darcis, Gilles
AU - Van der Auwera, Gert
AU - Giot, Jean-Baptiste
AU - Hayette, Marie-Pierre
AU - Tassin, Francoise
AU - Estrada, Jorge Arrese
AU - Cnops, Lieselotte
AU - Moutschen, Michel
AU - de Leval, Laurence
AU - Leonard, Philippe
N1 - FTX; DOAJ
PY - 2017
Y1 - 2017
N2 - Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or malignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively.Case presentation: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent.Conclusions: Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients.
AB - Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or malignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively.Case presentation: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent.Conclusions: Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients.
KW - Cutaneous leishmaniasis
KW - Mucosal leishmaniasis
KW - Visceral leishmaniasis
KW - Immunosuppression
KW - Parasitology
KW - Microbiology
KW - MUCOSAL LEISHMANIASIS
KW - INFANTUM
KW - HIV
U2 - 10.1186/s12879-017-2571-x
DO - 10.1186/s12879-017-2571-x
M3 - A1: Web of Science-article
SN - 1471-2334
VL - 17
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
M1 - 478
ER -