Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017

Brecht Ingelbeen; David Hendrickx; Berthe Miwanda; Marianne van der Sande; Mathias Mossoko; Hilde Vochten; Bram Riems; Jean-Paul Nyakio; Veerle Vanlerberghe; Octavie Lunguya; Jan Jacobs; Marleen Boelaert; Benoît Ilunga Kebela; Didier Bompangue; Jean-Jacques Muyembe

doi:10.3201/eid2505.181141

Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017

Brecht Ingelbeen, David Hendrickx, Berthe Miwanda, Marianne van der Sande, Mathias Mossoko, Hilde Vochten, Bram Riems, Jean-Paul Nyakio, Veerle Vanlerberghe, Octavie Lunguya, Jan Jacobs, Marleen Boelaert, Benoît Ilunga Kebela, Didier Bompangue, Jean-Jacques Muyembe

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Abstract

In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.

Original language	English
Journal	Emerging Infectious Diseases
Volume	25
Issue number	5
Pages (from-to)	856-864
Number of pages	9
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2505.181141
Publication status	Published - 2019

Keywords

Age Factors
Child
Child, Preschool
Cholera/epidemiology
Democratic Republic of the Congo/epidemiology
Disease Outbreaks
Geography, Medical
History, 21st Century
Humans
Incidence
Infant
Male
Public Health Surveillance
Recurrence

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10.3201/eid2505.181141Licence: CC BY

2019eidi0856Final published version, 8.14 MBLicence: CC BY

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Ingelbeen, B., Hendrickx, D., Miwanda, B., van der Sande, M., Mossoko, M., Vochten, H., Riems, B., Nyakio, J.-P., Vanlerberghe, V., Lunguya, O., Jacobs, J., Boelaert, M., Kebela, B. I., Bompangue, D., & Muyembe, J.-J. (2019). Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017. Emerging Infectious Diseases, 25(5), 856-864. https://doi.org/10.3201/eid2505.181141

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abstract = "In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.",

keywords = "Age Factors, Child, Child, Preschool, Cholera/epidemiology, Democratic Republic of the Congo/epidemiology, Disease Outbreaks, Geography, Medical, History, 21st Century, Humans, Incidence, Infant, Male, Public Health Surveillance, Recurrence",

author = "Brecht Ingelbeen and David Hendrickx and Berthe Miwanda and {van der Sande}, Marianne and Mathias Mossoko and Hilde Vochten and Bram Riems and Jean-Paul Nyakio and Veerle Vanlerberghe and Octavie Lunguya and Jan Jacobs and Marleen Boelaert and Kebela, {Beno{\^i}t Ilunga} and Didier Bompangue and Jean-Jacques Muyembe",

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Ingelbeen, B, Hendrickx, D, Miwanda, B, van der Sande, M, Mossoko, M, Vochten, H, Riems, B, Nyakio, J-P, Vanlerberghe, V, Lunguya, O, Jacobs, J, Boelaert, M, Kebela, BI, Bompangue, D & Muyembe, J-J 2019, 'Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017', Emerging Infectious Diseases, vol. 25, no. 5, pp. 856-864. https://doi.org/10.3201/eid2505.181141

TY - JOUR

T1 - Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017

AU - Ingelbeen, Brecht

AU - Hendrickx, David

AU - Miwanda, Berthe

AU - van der Sande, Marianne

AU - Mossoko, Mathias

AU - Vochten, Hilde

AU - Riems, Bram

AU - Nyakio, Jean-Paul

AU - Vanlerberghe, Veerle

AU - Lunguya, Octavie

AU - Jacobs, Jan

AU - Boelaert, Marleen

AU - Kebela, Benoît Ilunga

AU - Bompangue, Didier

AU - Muyembe, Jean-Jacques

N1 - FTX; DOAJ; CUNIT; (CC BY 4.0)

PY - 2019

Y1 - 2019

N2 - In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.

AB - In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.

KW - Age Factors

KW - Child

KW - Child, Preschool

KW - Cholera/epidemiology

KW - Democratic Republic of the Congo/epidemiology

KW - Disease Outbreaks

KW - Geography, Medical

KW - History, 21st Century

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Public Health Surveillance

KW - Recurrence

U2 - 10.3201/eid2505.181141

DO - 10.3201/eid2505.181141

M3 - A1: Web of Science-article

C2 - 31002075

SN - 1080-6040

VL - 25

SP - 856

EP - 864

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Recurrent cholera outbreaks, Democratic Republic of the Congo, 2008-2017

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Keywords

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