Abstract
Neutralizing antibody patterns in sera of persons infected with human immunodeficiency virus type 1 (HIV-1) groups M and O to their homologous and heterologous primary isolates were determined in a peripheral blood mononuclear cell-based neutralization assay and correlated with their ability to bind to V3 loop synthetic peptides. Most HIV-1 group M sera (9/16) neutralized HIV-1 group O viruses, whereas fewer group O sera (3/13) only weakly neutralized HIV-1 group M viruses. Group M sera neutralizing HIV-1 group O viruses neutralized other HIV-1 group M viruses with titers of 1:10–1:1280. V3 loop binding capacity of sera did not reflect their neutralizing capacity of the homologous isolate. Despite the reduced neutralizing capacity of group O-infected patients' sera to group M viruses, some group M-infected patients' sera neutralized both HIV-1 group M and O isolates, suggesting that they share some conserved neutralizing epitopes.
Original language | English |
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Journal | Journal of Infectious Diseases |
Volume | 172 |
Issue number | 5 |
Pages (from-to) | 1228-1237 |
Number of pages | 10 |
ISSN | 0022-1899 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- B780-tropical-medicine
- Virology
- HIV-1
- Group O
- Group M
- Neutralizing antibodies