Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

J S Biswas; A Patel; J A Otter; P Wade; W Newsholme; Esther van Kleef; S D Goldenberg

doi:10.1016/j.jhin.2015.01.015

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

J S Biswas, A Patel, J A Otter, P Wade, W Newsholme, Esther van Kleef, S D Goldenberg

Research output: Contribution to journal › A1: Web of Science-article › peer-review

25 Downloads (Pure)

Abstract

Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.

Original language	English
Journal	Journal of Hospital Infection
Volume	90
Issue number	3
Pages (from-to)	267-70
Number of pages	4
ISSN	0195-6701
DOIs	https://doi.org/10.1016/j.jhin.2015.01.015
Publication status	Published - 2015

Keywords

Adult
Aminoglycosides/therapeutic use
Anti-Bacterial Agents/therapeutic use
Clostridioides difficile/drug effects
Clostridium Infections/drug therapy
Cross Infection/microbiology
Diarrhea/drug therapy
Environmental Microbiology
Female
Fidaxomicin
Hospitalization
Humans
Male
Metronidazole/therapeutic use
Vancomycin/therapeutic use

Access to Document

10.1016/j.jhin.2015.01.015Licence: CC BY-NC-ND

2015jhin0267Final published version, 207 KBLicence: CC BY-NC-ND

Cite this

@article{d79be185577348c0bb072556763bcffe,

title = "Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin",

abstract = "Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.",

keywords = "Adult, Aminoglycosides/therapeutic use, Anti-Bacterial Agents/therapeutic use, Clostridioides difficile/drug effects, Clostridium Infections/drug therapy, Cross Infection/microbiology, Diarrhea/drug therapy, Environmental Microbiology, Female, Fidaxomicin, Hospitalization, Humans, Male, Metronidazole/therapeutic use, Vancomycin/therapeutic use",

author = "Biswas, {J S} and A Patel and Otter, {J A} and P Wade and W Newsholme and {van Kleef}, Esther and Goldenberg, {S D}",

year = "2015",

doi = "10.1016/j.jhin.2015.01.015",

language = "English",

volume = "90",

pages = "267--70",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

AU - Biswas, J S

AU - Patel, A

AU - Otter, J A

AU - Wade, P

AU - Newsholme, W

AU - van Kleef, Esther

AU - Goldenberg, S D

PY - 2015

Y1 - 2015

N2 - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.

AB - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.

KW - Adult

KW - Aminoglycosides/therapeutic use

KW - Anti-Bacterial Agents/therapeutic use

KW - Clostridioides difficile/drug effects

KW - Clostridium Infections/drug therapy

KW - Cross Infection/microbiology

KW - Diarrhea/drug therapy

KW - Environmental Microbiology

KW - Female

KW - Fidaxomicin

KW - Hospitalization

KW - Humans

KW - Male

KW - Metronidazole/therapeutic use

KW - Vancomycin/therapeutic use

U2 - 10.1016/j.jhin.2015.01.015

DO - 10.1016/j.jhin.2015.01.015

M3 - A1: Web of Science-article

C2 - 25728208

SN - 0195-6701

VL - 90

SP - 267

EP - 270

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 3

ER -

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

Abstract

Keywords

Access to Document

Fingerprint

Cite this