Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

J S Biswas, A Patel, J A Otter, P Wade, W Newsholme, Esther van Kleef, S D Goldenberg

    Research output: Contribution to journalA1: Web of Science-articlepeer-review


    Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.

    Original languageEnglish
    JournalJournal of Hospital Infection
    Issue number3
    Pages (from-to)267-70
    Number of pages4
    Publication statusPublished - 2015


    • Adult
    • Aminoglycosides/therapeutic use
    • Anti-Bacterial Agents/therapeutic use
    • Clostridioides difficile/drug effects
    • Clostridium Infections/drug therapy
    • Cross Infection/microbiology
    • Diarrhea/drug therapy
    • Environmental Microbiology
    • Female
    • Fidaxomicin
    • Hospitalization
    • Humans
    • Male
    • Metronidazole/therapeutic use
    • Vancomycin/therapeutic use

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