Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone

Cari Stek; Muki Shey; Khuthala Mnika; Charlotte Schutz; Friedrich Thienemann; Robert J Wilkinson; Lutgarde Lynen; Graeme Meintjes

doi:10.1093/ofid/ofad379

Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone

Cari Stek
, Muki Shey
, Khuthala Mnika
, Charlotte Schutz
, Friedrich Thienemann
, Robert J Wilkinson
, Lutgarde Lynen
, Graeme Meintjes

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.

Original language	English
Article number	ofad379
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	7
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofad379
Publication status	Published - 2023

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10.1093/ofid/ofad379Licence: CC BY

2023ofidofad379Final published version, 399 KBLicence: CC BY

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title = "Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone",

abstract = "The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.",

author = "Cari Stek and Muki Shey and Khuthala Mnika and Charlotte Schutz and Friedrich Thienemann and Wilkinson, \{Robert J\} and Lutgarde Lynen and Graeme Meintjes",

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T1 - Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone

AU - Stek, Cari

AU - Shey, Muki

AU - Mnika, Khuthala

AU - Schutz, Charlotte

AU - Thienemann, Friedrich

AU - Wilkinson, Robert J

AU - Lynen, Lutgarde

AU - Meintjes, Graeme

N1 - FTX; DOAJ; (CC BY 4.0); © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2023

Y1 - 2023

N2 - The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.

AB - The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.

U2 - 10.1093/ofid/ofad379

DO - 10.1093/ofid/ofad379

M3 - A1: Peer-reviewed journal articles

C2 - 37520416

SN - 2328-8957

VL - 10

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 7

M1 - ofad379

ER -

Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone

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