Residual activity and integrity of PermaNet((R)) 2.0 after 24 months of household use in a community randomised trial of long lasting insecticidal nets against visceral leishmaniasis in India and Nepal

A. Picado, SP Singh, V Vanlerberghe, S Uranw, B Ostyn, H Kaur, ML Das, S Sundar, S Rijal, P Tungu, M Boelaert, M Rowland

Research output: Contribution to journalA1: Web of Science-article

Abstract

The World Health Organization (WHO) recommends several brands of long lasting insecticidal net (LN) for protection against insect vectors but also advises national programmes to monitor and evaluate performance under local conditions to help them select the most suitable LN for their setting. During the course of a community randomised trial of LNs against visceral leishmaniasis in northern India and Nepal, opportunity arose to assess the efficacy of PermaNet 2.0 (Vestergaard-Frandsen, Denmark) after two years of use against sandfly vectors. Between 63% (India) and 78% (Nepal) of LNs became holed over the course of two years, deltamethrin residues fell from 55mg/m(2) to an average of 11.6mg/m(2) (India) and 27.9mg/m(2) (Nepal), but on the basis of bioassay criteria all LNs tested still met the WHO Pesticide Evaluation Scheme standard for LN effectiveness. Nets had on average only been washed 2.5 times (India) and 0.6 times (Nepal) by householders over the course of two years. The loss of insecticide was attributed to factors which had little or nothing to do with washing, such as handling, friction and torsion during daily use. Under conditions pertaining in this region of south Asia, and for two years at least, this brand of net continues to meet the criteria established by WHO for LNs.
Original languageEnglish
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume106
Issue number3
Pages (from-to)150-159
ISSN0035-9203
DOIs
Publication statusPublished - 2012

Keywords

  • B780-tropical-medicine
  • Protozoal diseases
  • Visceral
  • Leishmaniasis
  • Kala azar
  • Leishmania donovani
  • Vectors
  • Sandflies
  • Phlebotomus argentipes
  • Prevention strategies
  • Long-lasting nets
  • Insecticides
  • Deltamethrin
  • Households
  • Efficacy
  • Randomized controlled trials
  • India
  • Nepal
  • Asia-South

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