Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species

G François; T Steenackers; G Timperman; L Aké Assi; RD Haller; S Bär; MA Isahakia; SA Robertson; C Zhao; NJ De Souza; J Holenz; G Bringmann

doi:10.1016/S0020-7519(96)00171-3

Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species

G François, T Steenackers, G Timperman, L Aké Assi, RD Haller, S Bär, MA Isahakia, SA Robertson, C Zhao, NJ De Souza, J Holenz, G Bringmann

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Naphthylisoquinoline alkaloid-containing extracts (10 mu g ml(-1)) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH2Cl2/NH3 leaf extract from Triphyophyllum peltatum, a CH2Cl2/NH3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7-70.0%. The commercially available drug primaquine diphosphate (25 mu g ml(-1)) caused a comparable effect (62.1%) in the same test system. Copyright (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.

Original language	English
Journal	International Journal for Parasitology
Volume	27
Issue number	1
Pages (from-to)	29-32
Number of pages	4
ISSN	0020-7519
DOIs	https://doi.org/10.1016/S0020-7519(96)00171-3
Publication status	Published - 1997

Keywords

B780-tropical-medicine
Protozoology
Plasmodium berghei
Malaria
Protozoal diseases
Experimental
Hepatoma cells
Medicinal plants
Chemoprophylaxis

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10.1016/S0020-7519(96)00171-3

http://lib.itg.be/pdf/itg/1997/1997ijpa0029.pdf

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François, G., Steenackers, T., Timperman, G., Aké Assi, L., Haller, RD., Bär, S., Isahakia, MA., Robertson, SA., Zhao, C., De Souza, NJ., Holenz, J., & Bringmann, G. (1997). Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species. International Journal for Parasitology, 27(1), 29-32. https://doi.org/10.1016/S0020-7519(96)00171-3

@article{f68825329edd4be1b1877b73b1cd1233,

title = "Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species",

abstract = "Naphthylisoquinoline alkaloid-containing extracts (10 mu g ml(-1)) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH2Cl2/NH3 leaf extract from Triphyophyllum peltatum, a CH2Cl2/NH3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7-70.0%. The commercially available drug primaquine diphosphate (25 mu g ml(-1)) caused a comparable effect (62.1%) in the same test system. Copyright (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.",

keywords = "B780-tropical-medicine, Protozoology, Plasmodium berghei, Malaria, Protozoal diseases, Experimental, Hepatoma cells, Medicinal plants, Chemoprophylaxis",

author = "G Fran{\c c}ois and T Steenackers and G Timperman and {Ak{\'e} Assi}, L and RD Haller and S B{\"a}r and MA Isahakia and SA Robertson and C Zhao and {De Souza}, NJ and J Holenz and G Bringmann",

note = "FTX: Abonnement",

year = "1997",

doi = "10.1016/S0020-7519(96)00171-3",

language = "English",

volume = "27",

pages = "29--32",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier",

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François, G, Steenackers, T, Timperman, G, Aké Assi, L, Haller, RD, Bär, S, Isahakia, MA, Robertson, SA, Zhao, C, De Souza, NJ, Holenz, J & Bringmann, G 1997, 'Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species', International Journal for Parasitology, vol. 27, no. 1, pp. 29-32. https://doi.org/10.1016/S0020-7519(96)00171-3

Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species. / François, G; Steenackers, T; Timperman, G et al.
In: International Journal for Parasitology, Vol. 27, No. 1, 1997, p. 29-32.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species

AU - François, G

AU - Steenackers, T

AU - Timperman, G

AU - Aké Assi, L

AU - Haller, RD

AU - Bär, S

AU - Isahakia, MA

AU - Robertson, SA

AU - Zhao, C

AU - De Souza, NJ

AU - Holenz, J

AU - Bringmann, G

N1 - FTX: Abonnement

PY - 1997

Y1 - 1997

N2 - Naphthylisoquinoline alkaloid-containing extracts (10 mu g ml(-1)) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH2Cl2/NH3 leaf extract from Triphyophyllum peltatum, a CH2Cl2/NH3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7-70.0%. The commercially available drug primaquine diphosphate (25 mu g ml(-1)) caused a comparable effect (62.1%) in the same test system. Copyright (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.

AB - Naphthylisoquinoline alkaloid-containing extracts (10 mu g ml(-1)) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH2Cl2/NH3 leaf extract from Triphyophyllum peltatum, a CH2Cl2/NH3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7-70.0%. The commercially available drug primaquine diphosphate (25 mu g ml(-1)) caused a comparable effect (62.1%) in the same test system. Copyright (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.

KW - B780-tropical-medicine

KW - Protozoology

KW - Plasmodium berghei

KW - Malaria

KW - Protozoal diseases

KW - Experimental

KW - Hepatoma cells

KW - Medicinal plants

KW - Chemoprophylaxis

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1997WL62200003

U2 - 10.1016/S0020-7519(96)00171-3

DO - 10.1016/S0020-7519(96)00171-3

M3 - A1: Web of Science-article

SN - 0020-7519

VL - 27

SP - 29

EP - 32

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 1

ER -

Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceaea and Ancistrocladaceae species

Abstract

Keywords

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