Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium

ITM Monkeypox Study Group

Research output: Contribution to journalA1: Web of Science-articlepeer-review

Abstract

The magnitude of the 2022 multi-country monkeypox virus (MPXV) outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. In this study, we aimed to assess whether undiagnosed infections occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhea and chlamydia testing using an MPXV PCR assay and identified MPXV-DNA-positive samples from four men. At the time of sampling, one man had a painful rash, and three men had reported no symptoms. Upon clinical examination 21-37 days later, these three men were free of clinical signs, and they reported not having experienced any symptoms. Serology confirmed MPXV exposure in all three men, and MPXV was cultured from two cases. These findings show that certain cases of monkeypox remain undiagnosed and suggest that testing and quarantining of individuals reporting symptoms may not suffice to contain the outbreak.

Original languageEnglish
Article number1081
JournalNature Medicine
Volume28
Issue number11
Pages (from-to)2288-2292
Number of pages5
ISSN1078-8956
DOIs
Publication statusPublished - Nov-2022

Keywords

  • Belgium/epidemiology
  • Humans
  • Male
  • Monkeypox virus
  • Monkeypox/diagnosis
  • Retrospective Studies
  • Sexual Health

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