Risk factors for visceral leishmaniasis and asymptomatic Leishmania donovani infection in India and Nepal

Albert Picado, Bart Ostyn, Shri Prakash Singh, Surendra Uranw, Epco Hasker, Suman Rijal, Shyam Sundar, Marleen Boelaert, François Chappuis

    Research output: Contribution to journalA1: Web of Science-article

    7 Downloads (Pure)

    Abstract

    There is increasing interest in the role of asymptomatic infection in transmission of Visceral Leishmaniasis (VL). We studied the individual, household and environmental factors associated with asymptomatic Leishmania donovani infected individuals and VL. 7,538 individuals living in VL endemic villages in India and Nepal were divided into three mutually exclusive groups based on their VL history and Direct Agglutination Test (DAT) results in yearly serosurveys over a two-year period. The groups were (1) VL cases, (2) asymptomatically infected individuals (seroconverters) and (3) seronegative individuals. VL cases and seroconverters were compared to seronegative individuals in mixed logistic regression models. The risk of seroconversion and disease was significantly increased in individuals aged 14 to 24 years old and by the presence of other DAT-positive, asymptomatically infected individuals and VL cases in the house. The risk of seroconversion was higher in Indian than in Nepalese villages and it increased significantly with age, but not so for VL. This study demonstrates that, when risk factors for leishmanial infection and VL disease are evaluated in the same population, epidemiological determinants for asymptomatic infection and VL are largely similar.

    Original languageEnglish
    JournalPLoS ONE
    Volume9
    Issue number1
    Pages (from-to)e87641
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2014

    Fingerprint Dive into the research topics of 'Risk factors for visceral leishmaniasis and asymptomatic <i>Leishmania donovani</i> infection in India and Nepal'. Together they form a unique fingerprint.

    Cite this