Salmonella infections in The Gambia, 2005-2015

B. Kwambana-Adams, S. Darboe, H. Nabwera, E. Foster-Nyarko, U.N. Ikumapayi, O. Secka, M. Betts, R. Bradbury, R. Wegm�ller, B. Lawal, D. Saha, M.J. Hossain, A.M. Prentice, B. Kampmann, S. Anderson, Umberto D'Alessandro, M. Antonio

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    BACKGROUND: There are large data gaps in the epidemiology of diseases caused by Salmonella enterica in West Africa. Regional surveillance of Salmonella infections is necessary, especially with the emergence and spread of multidrug-resistant clones. METHODS: Data on Salmonella isolated from various clinical specimens from patients from across The Gambia were collected and analyzed retrospectively from 2005 to April 2015. Antibiotic sensitivity testing of Salmonella isolates was performed by disk diffusion method. Serotyping and serogrouping of Salmonella isolates was performed using standard microbiology techniques. RESULTS: Two hundred three Salmonella isolates were isolated from 190 patients: 52% (106/203) from blood and 39% (79/203) from stool specimens. Salmonella was also isolated from urine, aspirates, cerebrospinal fluid, wounds, and abscesses. The prevalence of Salmonella in blood cultures was 0.8% (106/13 905). Of the serotyped salmonellae, 14% (21/152) were Salmonella enterica serovar Typhi, whereas 86% (131/152) were serovars other than Typhi (nontyphoidal Salmonella). Of the 102 typed NTS isolates, 40% (41) were Salmonella enterica serovar Typhimurium, 10% (10) were Salmonella enterica serovar Enteritidis, and 3% (3) were Salmonella enterica serovar Arizonae. Overall, 70% (142/203) of the salmonellae were pansusceptible. Multidrug resistance was found in 4% (9/203) of the isolates, 3 of which were Salmonella Enteritidis. CONCLUSIONS: Salmonellae are associated with a wide spectrum of invasive and noninvasive infections across all ages in The Gambia. There is evidence of multidrug resistance in salmonellae that warrants vigilant monitoring and surveillance.
    Original languageEnglish
    JournalClinical Infectious Diseases
    Volume61
    Issue numberSuppl. 4
    Pages (from-to)S354-S362
    Number of pages9
    ISSN1058-4838
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Bacterial diseases
    • Salmonella
    • Salmonella enterica
    • Salmonella typhi
    • Salmonella typhimurium
    • Epidemiology
    • Multidrug resistance
    • Serotyping
    • Serogroups
    • Gambia
    • Africa-West

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