SARS-associated coronavirus transmission, United States

SARS Investigation Group

Research output: Contribution to journalA1: Web of Science-articlepeer-review


To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

Original languageEnglish
JournalEmerging Infectious Diseases
Issue number2
Pages (from-to)225-231
Number of pages7
Publication statusPublished - 2004


  • Adolescent
  • Adult
  • Child
  • Contact Tracing
  • Disease Outbreaks
  • Family Characteristics
  • Feces/virology
  • Female
  • Humans
  • Male
  • Middle Aged
  • SARS Virus/isolation & purification
  • Severe Acute Respiratory Syndrome/epidemiology
  • Sputum/virology
  • Time Factors
  • United States/epidemiology


Dive into the research topics of 'SARS-associated coronavirus transmission, United States'. Together they form a unique fingerprint.

Cite this