Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota

Crispin Mukerebe; Alexandra A Cordeiro; Christine Aristide; Soledad Colombe; Brooke W Bullington; Samuel Kalluvya; Govert J van Dam; Claudia J de Dood; Paul L A M Corstjens; Jane K Maganga; John M Changalucha; Lucy A Namkinga; Victor Anacletus Makene; Myung Hee Lee; Jennifer A Downs

doi:10.1093/infdis/jiaf447

Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota

Crispin Mukerebe, Alexandra A Cordeiro, Christine Aristide, Soledad Colombe, Brooke W Bullington, Samuel Kalluvya, Govert J van Dam, Claudia J de Dood, Paul L A M Corstjens, Jane K Maganga, John M Changalucha, Lucy A Namkinga, Victor Anacletus Makene, Myung Hee Lee, Jennifer A Downs

Emerging Infectious Diseases

Research output: Contribution to journal › Article › peer-review

Abstract

Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.

Original language	English
Article number	jiaf447
Journal	Journal of Infectious Diseases
Number of pages	6
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiaf447
Publication status	E-pub ahead of print - 2025

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Mukerebe, C., Cordeiro, A. A., Aristide, C., Colombe, S., Bullington, B. W., Kalluvya, S., van Dam, G. J., de Dood, C. J., Corstjens, P. L. A. M., Maganga, J. K., Changalucha, J. M., Namkinga, L. A., Makene, V. A., Lee, M. H., & Downs, J. A. (2025). Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota. Journal of Infectious Diseases, Article jiaf447. Advance online publication. https://doi.org/10.1093/infdis/jiaf447

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title = "Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota",

abstract = "Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.",

author = "Crispin Mukerebe and Cordeiro, {Alexandra A} and Christine Aristide and Soledad Colombe and Bullington, {Brooke W} and Samuel Kalluvya and {van Dam}, {Govert J} and {de Dood}, {Claudia J} and Corstjens, {Paul L A M} and Maganga, {Jane K} and Changalucha, {John M} and Namkinga, {Lucy A} and Makene, {Victor Anacletus} and Lee, {Myung Hee} and Downs, {Jennifer A}",

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year = "2025",

doi = "10.1093/infdis/jiaf447",

language = "English",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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Mukerebe, C, Cordeiro, AA, Aristide, C, Colombe, S, Bullington, BW, Kalluvya, S, van Dam, GJ, de Dood, CJ, Corstjens, PLAM, Maganga, JK, Changalucha, JM, Namkinga, LA, Makene, VA, Lee, MH & Downs, JA 2025, 'Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota', Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaf447

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T1 - Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota

AU - Mukerebe, Crispin

AU - Cordeiro, Alexandra A

AU - Aristide, Christine

AU - Colombe, Soledad

AU - Bullington, Brooke W

AU - Kalluvya, Samuel

AU - van Dam, Govert J

AU - de Dood, Claudia J

AU - Corstjens, Paul L A M

AU - Maganga, Jane K

AU - Changalucha, John M

AU - Namkinga, Lucy A

AU - Makene, Victor Anacletus

AU - Lee, Myung Hee

AU - Downs, Jennifer A

N1 - FTX: Abonnement

PY - 2025

Y1 - 2025

N2 - Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.

AB - Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a pre-requisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9-12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (Odds ratio (OR): 4.7 [1.3-16.5], p=0.017) and Gardnerella-dominant microbiome (p=0.049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001577974700001

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DO - 10.1093/infdis/jiaf447

M3 - Article

C2 - 40842278

SN - 0022-1899

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

M1 - jiaf447

ER -

Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota

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