Screening for Trypanosoma brucei gambiense antibodies with the indirect fluorescent antibody test (IFAT); effect of age and previous treatment

G Kegels, B Criel, W van Lerberghe, H Mentens, E Magnus, H Van Balen

Research output: Contribution to journalA1: Web of Science-article

Abstract

This paper reports on some of the findings of a longitudinal multi-round investigation into the predictive power of early signs and symptoms of human African trypanosomiasis caused by T.b. gambiense, in the Rural Health Zone of Kasongo (Maniema, Zaire). It assesses the importance of the effect of age and a history of previously treated sleeping sickness on serological positivity as measured by the Indirect Fluorescent Antibody Test (IFAT), used as a screening test. The impact of including age and a history of previous sleeping sickness as part of the screening process is discussed in terms of sensitivity and positive predictive value. Including weak serological positivity among the screening criteria does not appear to improve the sensitivity of the IFAT test in this setting
Original languageEnglish
JournalAnnales de la Société Belge de Médecine Tropicale
Volume72
Pages (from-to)271-281
ISSN0365-6527
Publication statusPublished - 1992

Keywords

  • B780-tropical-medicine
  • Protozoal diseases
  • Trypanosomiasis
  • Trypanosoma brucei gambiense
  • Screening
  • Serology
  • Fluorescent antibody technique
  • IFAT
  • Congo-Kinshasa
  • Kasongo
  • Africa-Central

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