TY - JOUR
T1 - Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile
AU - Aragon Workers' Hlth Study Investi
AU - Leon-Latre, Montserrat
AU - Moreno-Franco, Belen
AU - Andres-Esteban, Eva M.
AU - Ledesma, Marta
AU - Laclaustra, Martin
AU - Alcalde, Victor
AU - Penalvo, Jose L.
AU - Ordovas, Jose M.
AU - Casasnovas, Jose A.
PY - 2014
Y1 - 2014
N2 - Introduction and objectives: To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.Methods: Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/ highdensity lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.Results: The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/ high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [b = 0.07], log homeostasis model assessment of insulin resistance index [b = 0.05], triglyceride/ high-density lipoprotein cholesterol ratio [b = 0.23], and insulin [b = 0.44]), which remained after adjustment for metabolic equivalents-h/ week.Conclusions: Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed. (C) 2013 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S. L. All rights reserved.
AB - Introduction and objectives: To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.Methods: Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/ highdensity lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.Results: The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/ high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [b = 0.07], log homeostasis model assessment of insulin resistance index [b = 0.05], triglyceride/ high-density lipoprotein cholesterol ratio [b = 0.23], and insulin [b = 0.44]), which remained after adjustment for metabolic equivalents-h/ week.Conclusions: Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed. (C) 2013 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S. L. All rights reserved.
KW - Sedentary lifestyle
KW - Cardiovascular risk
KW - Inflammation
KW - Insulin resistance
KW - PHYSICAL-ACTIVITY QUESTIONNAIRE
KW - DENSITY LIPOPROTEIN CHOLESTEROL
KW - C-REACTIVE PROTEIN
KW - HEALTH-PROFESSIONALS
KW - BEHAVIOR
KW - TIME
KW - REPRODUCIBILITY
KW - ASSOCIATION
KW - BIOMARKERS
KW - INACTIVITY
U2 - 10.1016/j.rec.2013.10.015
DO - 10.1016/j.rec.2013.10.015
M3 - A1: Web of Science-article
VL - 67
SP - 449
EP - 455
JO - Revista Española de Cardiología
JF - Revista Española de Cardiología
SN - 0300-8932
IS - 6
ER -