Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile

Aragon Workers' Hlth Study Investi

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Abstract

Introduction and objectives: To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.

Methods: Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/ highdensity lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.

Results: The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/ high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [b = 0.07], log homeostasis model assessment of insulin resistance index [b = 0.05], triglyceride/ high-density lipoprotein cholesterol ratio [b = 0.23], and insulin [b = 0.44]), which remained after adjustment for metabolic equivalents-h/ week.

Conclusions: Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed. (C) 2013 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S. L. All rights reserved.

Original languageEnglish
JournalRevista Española de Cardiología
Volume67
Issue number6
Pages (from-to)449-455
Number of pages7
ISSN0300-8932
DOIs
Publication statusPublished - 2014

Keywords

  • Sedentary lifestyle
  • Cardiovascular risk
  • Inflammation
  • Insulin resistance
  • PHYSICAL-ACTIVITY QUESTIONNAIRE
  • DENSITY LIPOPROTEIN CHOLESTEROL
  • C-REACTIVE PROTEIN
  • HEALTH-PROFESSIONALS
  • BEHAVIOR
  • TIME
  • REPRODUCIBILITY
  • ASSOCIATION
  • BIOMARKERS
  • INACTIVITY

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