Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee

M Vanden Haesevelde; M Peeters; G Jannes; W Janssens; G van der Groen; PM Sharp; E Saman

doi:10.1006/viro.1996.0384

Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee

M Vanden Haesevelde, M Peeters, G Jannes, W Janssens, G van der Groen, PM Sharp, E Saman

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIV_CPZ-GAB and SIV_CPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1-related virus, SIV_CPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIV_CPZ-GAB. Protein sequence identity with SIV_CPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIV_CPZ-GAB). The V3 regions of the SIV_CPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIV_CPZ-ANT did not show a greater degree of sequence similarity with SIV_CPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic

Original language	English
Journal	Virology
Volume	221
Issue number	2
Pages (from-to)	346-350
Number of pages	5
ISSN	0042-6822
DOIs	https://doi.org/10.1006/viro.1996.0384
Publication status	Published - 1996

Keywords

B780-tropical-medicine
Virology
Lentivirus
HIV-related viruses
SIV
Molecular sequence data
Base sequence
Amino acids
Primates
Chimpanzees
Congo-Kinshasa
Africa-Central

Access to Document

10.1006/viro.1996.0384

http://lib.itg.be/pdf/itg/1996/1996viro0346.pdf

Cite this

@article{d565627e226b4157adae4d1e61cf64d0,

title = "Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee",

abstract = "Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIVCPZ-GAB and SIVCPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1-related virus, SIVCPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIVCPZ-GAB. Protein sequence identity with SIVCPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIVCPZ-GAB). The V3 regions of the SIVCPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIVCPZ-ANT did not show a greater degree of sequence similarity with SIVCPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic",

keywords = "B780-tropical-medicine, Virology, Lentivirus, HIV-related viruses, SIV, Molecular sequence data, Base sequence, Amino acids, Primates, Chimpanzees, Congo-Kinshasa, Africa-Central",

author = "{Vanden Haesevelde}, M and M Peeters and G Jannes and W Janssens and {van der Groen}, G and PM Sharp and E Saman",

note = "FTX: Abonnement",

year = "1996",

doi = "10.1006/viro.1996.0384",

language = "English",

volume = "221",

pages = "346--350",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee

AU - Vanden Haesevelde, M

AU - Peeters, M

AU - Jannes, G

AU - Janssens, W

AU - van der Groen, G

AU - Sharp, PM

AU - Saman, E

N1 - FTX: Abonnement

PY - 1996

Y1 - 1996

N2 - Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIVCPZ-GAB and SIVCPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1-related virus, SIVCPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIVCPZ-GAB. Protein sequence identity with SIVCPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIVCPZ-GAB). The V3 regions of the SIVCPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIVCPZ-ANT did not show a greater degree of sequence similarity with SIVCPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic

AB - Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIVCPZ-GAB and SIVCPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1-related virus, SIVCPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIVCPZ-GAB. Protein sequence identity with SIVCPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIVCPZ-GAB). The V3 regions of the SIVCPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIVCPZ-ANT did not show a greater degree of sequence similarity with SIVCPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic

KW - B780-tropical-medicine

KW - Virology

KW - Lentivirus

KW - HIV-related viruses

KW - SIV

KW - Molecular sequence data

KW - Base sequence

KW - Amino acids

KW - Primates

KW - Chimpanzees

KW - Congo-Kinshasa

KW - Africa-Central

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1996UX89200011

U2 - 10.1006/viro.1996.0384

DO - 10.1006/viro.1996.0384

M3 - A1: Web of Science-article

SN - 0042-6822

VL - 221

SP - 346

EP - 350

JO - Virology

JF - Virology

IS - 2

ER -

Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this