Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study

Sofie H Mooij; Fiona R M van der Klis; Marianne A B van der Sande; Rutger M Schepp; Arjen G C L Speksnijder; Johannes A Bogaards; Hester E de Melker; Henry J C de Vries; Peter J F Snijders; Maarten F Schim van der Loeff

doi:10.1158/1055-9965.EPI-13-0460

Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study

Sofie H Mooij, Fiona R M van der Klis, Marianne A B van der Sande, Rutger M Schepp, Arjen G C L Speksnijder, Johannes A Bogaards, Hester E de Melker, Henry J C de Vries, Peter J F Snijders, Maarten F Schim van der Loeff

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

BACKGROUND: Men who have sex with men (MSM), in particular HIV-infected MSM, are at increased risk for diseases related to human papilloma virus (HPV). Our goal was to assess the effect of HIV status on the presence of type-specific antibodies against seven high-risk HPV types in HPV-unvaccinated MSM. Moreover, we compared determinants of HPV seropositivity between HIV-negative and HIV-infected MSM.

METHODS: MSM ≥18 years of age were recruited from the Amsterdam Cohort Studies, a sexually transmitted infection clinic, and an HIV-treatment center in Amsterdam, the Netherlands. Participants completed a risk-factor questionnaire; serum samples were analyzed using a fluorescent bead-based multiplex assay.

RESULTS: MSM (n = 795) were recruited in 2010 to 2011; 758 MSM were included in this analysis. Median age was 40.1 years (interquartile range 34.8-47.5) and 308 MSM (40.6%) were HIV-infected. Seroprevalence of HPV-16 was 37.1% in HIV-negative and 62.7% in HIV-infected MSM (P < 0.001); seroprevalence of HPV-18 was 29.1% in HIV-negative MSM and 42.5% in HIV-infected MSM (P < 0.001). Similar patterns of seroprevalence were observed for HPV types 31, 33, 45, 52, and 58. In multivariable analyses, HPV seropositivity was associated with HIV infection [adjusted OR = 2.1; 95% confidence interval, 1.6-2.6]. In multivariable analyses stratified by HIV status, increasing age and number of lifetime male sex partners were significantly associated with HPV seropositivity in HIV-negative, but not HIV-infected MSM.

CONCLUSIONS: Seroprevalence of high-risk HPV types is high among unvaccinated MSM.

IMPACT: HIV infection is a strong and independent determinant for HPV seropositivity, which we hypothesize is because of increased persistence of HPV infection in HIV-infected MSM.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	22
Issue number	10
Pages (from-to)	1698-1708
Number of pages	11
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-13-0460
Publication status	Published - 2013

Keywords

Adult
HIV Infections/epidemiology
Homosexuality, Male/statistics & numerical data
Humans
Male
Middle Aged
Netherlands/epidemiology
Papillomaviridae/isolation & purification
Papillomavirus Infections/epidemiology
Risk Factors
Seroepidemiologic Studies

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Mooij, S. H., van der Klis, F. R. M., van der Sande, M. A. B., Schepp, R. M., Speksnijder, A. G. C. L., Bogaards, J. A., de Melker, H. E., de Vries, H. J. C., Snijders, P. J. F., & van der Loeff, M. F. S. (2013). Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study. Cancer Epidemiology, Biomarkers & Prevention, 22(10), 1698-1708. https://doi.org/10.1158/1055-9965.EPI-13-0460

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title = "Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study",

abstract = "BACKGROUND: Men who have sex with men (MSM), in particular HIV-infected MSM, are at increased risk for diseases related to human papilloma virus (HPV). Our goal was to assess the effect of HIV status on the presence of type-specific antibodies against seven high-risk HPV types in HPV-unvaccinated MSM. Moreover, we compared determinants of HPV seropositivity between HIV-negative and HIV-infected MSM.METHODS: MSM ≥18 years of age were recruited from the Amsterdam Cohort Studies, a sexually transmitted infection clinic, and an HIV-treatment center in Amsterdam, the Netherlands. Participants completed a risk-factor questionnaire; serum samples were analyzed using a fluorescent bead-based multiplex assay.RESULTS: MSM (n = 795) were recruited in 2010 to 2011; 758 MSM were included in this analysis. Median age was 40.1 years (interquartile range 34.8-47.5) and 308 MSM (40.6%) were HIV-infected. Seroprevalence of HPV-16 was 37.1% in HIV-negative and 62.7% in HIV-infected MSM (P < 0.001); seroprevalence of HPV-18 was 29.1% in HIV-negative MSM and 42.5% in HIV-infected MSM (P < 0.001). Similar patterns of seroprevalence were observed for HPV types 31, 33, 45, 52, and 58. In multivariable analyses, HPV seropositivity was associated with HIV infection [adjusted OR = 2.1; 95% confidence interval, 1.6-2.6]. In multivariable analyses stratified by HIV status, increasing age and number of lifetime male sex partners were significantly associated with HPV seropositivity in HIV-negative, but not HIV-infected MSM.CONCLUSIONS: Seroprevalence of high-risk HPV types is high among unvaccinated MSM.IMPACT: HIV infection is a strong and independent determinant for HPV seropositivity, which we hypothesize is because of increased persistence of HPV infection in HIV-infected MSM.",

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author = "Mooij, {Sofie H} and {van der Klis}, {Fiona R M} and {van der Sande}, {Marianne A B} and Schepp, {Rutger M} and Speksnijder, {Arjen G C L} and Bogaards, {Johannes A} and {de Melker}, {Hester E} and {de Vries}, {Henry J C} and Snijders, {Peter J F} and {van der Loeff}, {Maarten F Schim}",

note = "FTX",

year = "2013",

doi = "10.1158/1055-9965.EPI-13-0460",

language = "English",

volume = "22",

pages = "1698--1708",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "10",

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Mooij, SH, van der Klis, FRM, van der Sande, MAB, Schepp, RM, Speksnijder, AGCL, Bogaards, JA, de Melker, HE, de Vries, HJC, Snijders, PJF & van der Loeff, MFS 2013, 'Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study', Cancer Epidemiology, Biomarkers & Prevention, vol. 22, no. 10, pp. 1698-1708. https://doi.org/10.1158/1055-9965.EPI-13-0460

TY - JOUR

T1 - Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study

AU - Mooij, Sofie H

AU - van der Klis, Fiona R M

AU - van der Sande, Marianne A B

AU - Schepp, Rutger M

AU - Speksnijder, Arjen G C L

AU - Bogaards, Johannes A

AU - de Melker, Hester E

AU - de Vries, Henry J C

AU - Snijders, Peter J F

AU - van der Loeff, Maarten F Schim

N1 - FTX

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Men who have sex with men (MSM), in particular HIV-infected MSM, are at increased risk for diseases related to human papilloma virus (HPV). Our goal was to assess the effect of HIV status on the presence of type-specific antibodies against seven high-risk HPV types in HPV-unvaccinated MSM. Moreover, we compared determinants of HPV seropositivity between HIV-negative and HIV-infected MSM.METHODS: MSM ≥18 years of age were recruited from the Amsterdam Cohort Studies, a sexually transmitted infection clinic, and an HIV-treatment center in Amsterdam, the Netherlands. Participants completed a risk-factor questionnaire; serum samples were analyzed using a fluorescent bead-based multiplex assay.RESULTS: MSM (n = 795) were recruited in 2010 to 2011; 758 MSM were included in this analysis. Median age was 40.1 years (interquartile range 34.8-47.5) and 308 MSM (40.6%) were HIV-infected. Seroprevalence of HPV-16 was 37.1% in HIV-negative and 62.7% in HIV-infected MSM (P < 0.001); seroprevalence of HPV-18 was 29.1% in HIV-negative MSM and 42.5% in HIV-infected MSM (P < 0.001). Similar patterns of seroprevalence were observed for HPV types 31, 33, 45, 52, and 58. In multivariable analyses, HPV seropositivity was associated with HIV infection [adjusted OR = 2.1; 95% confidence interval, 1.6-2.6]. In multivariable analyses stratified by HIV status, increasing age and number of lifetime male sex partners were significantly associated with HPV seropositivity in HIV-negative, but not HIV-infected MSM.CONCLUSIONS: Seroprevalence of high-risk HPV types is high among unvaccinated MSM.IMPACT: HIV infection is a strong and independent determinant for HPV seropositivity, which we hypothesize is because of increased persistence of HPV infection in HIV-infected MSM.

AB - BACKGROUND: Men who have sex with men (MSM), in particular HIV-infected MSM, are at increased risk for diseases related to human papilloma virus (HPV). Our goal was to assess the effect of HIV status on the presence of type-specific antibodies against seven high-risk HPV types in HPV-unvaccinated MSM. Moreover, we compared determinants of HPV seropositivity between HIV-negative and HIV-infected MSM.METHODS: MSM ≥18 years of age were recruited from the Amsterdam Cohort Studies, a sexually transmitted infection clinic, and an HIV-treatment center in Amsterdam, the Netherlands. Participants completed a risk-factor questionnaire; serum samples were analyzed using a fluorescent bead-based multiplex assay.RESULTS: MSM (n = 795) were recruited in 2010 to 2011; 758 MSM were included in this analysis. Median age was 40.1 years (interquartile range 34.8-47.5) and 308 MSM (40.6%) were HIV-infected. Seroprevalence of HPV-16 was 37.1% in HIV-negative and 62.7% in HIV-infected MSM (P < 0.001); seroprevalence of HPV-18 was 29.1% in HIV-negative MSM and 42.5% in HIV-infected MSM (P < 0.001). Similar patterns of seroprevalence were observed for HPV types 31, 33, 45, 52, and 58. In multivariable analyses, HPV seropositivity was associated with HIV infection [adjusted OR = 2.1; 95% confidence interval, 1.6-2.6]. In multivariable analyses stratified by HIV status, increasing age and number of lifetime male sex partners were significantly associated with HPV seropositivity in HIV-negative, but not HIV-infected MSM.CONCLUSIONS: Seroprevalence of high-risk HPV types is high among unvaccinated MSM.IMPACT: HIV infection is a strong and independent determinant for HPV seropositivity, which we hypothesize is because of increased persistence of HPV infection in HIV-infected MSM.

KW - Adult

KW - HIV Infections/epidemiology

KW - Homosexuality, Male/statistics & numerical data

KW - Humans

KW - Male

KW - Middle Aged

KW - Netherlands/epidemiology

KW - Papillomaviridae/isolation & purification

KW - Papillomavirus Infections/epidemiology

KW - Risk Factors

KW - Seroepidemiologic Studies

U2 - 10.1158/1055-9965.EPI-13-0460

DO - 10.1158/1055-9965.EPI-13-0460

M3 - A1: Web of Science-article

C2 - 24097197

SN - 1055-9965

VL - 22

SP - 1698

EP - 1708

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 10

ER -

Seroepidemiology of high-risk HPV in HIV-negative and HIV-infected MSM: the H2M study

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