TY - JOUR
T1 - Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022
AU - ITM Monkeypox Study Group
AU - Berens-Riha, Nicole
AU - De Block, Tessa
AU - Rutgers, Jojanneke
AU - Michiels, Johan
AU - Van Gestel, Liesbeth
AU - Hens, Matilde
AU - Kenyon, Chris
AU - Bottieau, Emmanuel
AU - Soentjens, Patrick
AU - van Griensven, Johan
AU - Brosius, Isabel
AU - Ariën, Kevin K
AU - Van Esbroeck, Marjan
AU - Rezende, Antonio Mauro
AU - Vercauteren, Koen
AU - Liesenborghs, Laurens
N1 - FTX; DOAJ; (CC BY 4.0)
PY - 2022
Y1 - 2022
N2 - Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.
AB - Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.
KW - Humans
KW - Monkeypox/prevention & control
KW - Belgium/epidemiology
KW - Smallpox Vaccine
KW - Vaccination/adverse effects
U2 - 10.2807/1560-7917.ES.2022.27.48.2200894
DO - 10.2807/1560-7917.ES.2022.27.48.2200894
M3 - A1: Web of Science-article
C2 - 36695462
SN - 1560-7917
VL - 27
JO - Eurosurveillance
JF - Eurosurveillance
IS - 48
M1 - 2200894
ER -