Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

ITM Monkeypox Study Group

doi:10.2807/1560-7917.ES.2022.27.48.2200894

Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

ITM Monkeypox Study Group

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.

Original language	English
Article number	2200894
Journal	Eurosurveillance
Volume	27
Issue number	48
Number of pages	6
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.48.2200894
Publication status	Published - 2022

Keywords

Humans
Monkeypox/prevention & control
Belgium/epidemiology
Smallpox Vaccine
Vaccination/adverse effects

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10.2807/1560-7917.ES.2022.27.48.2200894Licence: CC BY

2022euro2200894Final published version, 351 KBLicence: CC BY

FWO MPX: Op zoek naar het mechanisme achter Monkeypox virus transmissie: een multidisciplinaire 'one health' studie over een opkomende zoönose
Liesenborghs, L. (PI), Bottieau, E. (Promotor) & Liesenborghs, L. (PI)
Research Fund - Flanders
1/01/22 → 31/12/27
Project: Research Project

Cite this

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title = "Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022",

abstract = "Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.",

keywords = "Humans, Monkeypox/prevention \& control, Belgium/epidemiology, Smallpox Vaccine, Vaccination/adverse effects",

author = "\{ITM Monkeypox Study Group\} and Nicole Berens-Riha and \{De Block\}, Tessa and Jojanneke Rutgers and Johan Michiels and \{Van Gestel\}, Liesbeth and Matilde Hens and Chris Kenyon and Emmanuel Bottieau and Patrick Soentjens and \{van Griensven\}, Johan and Isabel Brosius and Ari{\"e}n, \{Kevin K\} and \{Van Esbroeck\}, Marjan and Rezende, \{Antonio Mauro\} and Koen Vercauteren and Laurens Liesenborghs",

note = "FTX; DOAJ; (CC BY 4.0)",

year = "2022",

doi = "10.2807/1560-7917.ES.2022.27.48.2200894",

language = "English",

volume = "27",

journal = "Eurosurveillance",

issn = "1560-7917",

publisher = "European Centre for Disease Prevention \& Control",

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TY - JOUR

T1 - Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

AU - ITM Monkeypox Study Group

AU - Berens-Riha, Nicole

AU - De Block, Tessa

AU - Rutgers, Jojanneke

AU - Michiels, Johan

AU - Van Gestel, Liesbeth

AU - Hens, Matilde

AU - Kenyon, Chris

AU - Bottieau, Emmanuel

AU - Soentjens, Patrick

AU - van Griensven, Johan

AU - Brosius, Isabel

AU - Ariën, Kevin K

AU - Van Esbroeck, Marjan

AU - Rezende, Antonio Mauro

AU - Vercauteren, Koen

AU - Liesenborghs, Laurens

N1 - FTX; DOAJ; (CC BY 4.0)

PY - 2022

Y1 - 2022

N2 - Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.

AB - Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.

KW - Humans

KW - Monkeypox/prevention & control

KW - Belgium/epidemiology

KW - Smallpox Vaccine

KW - Vaccination/adverse effects

U2 - 10.2807/1560-7917.ES.2022.27.48.2200894

DO - 10.2807/1560-7917.ES.2022.27.48.2200894

M3 - A1: Peer-reviewed journal articles

C2 - 36695462

SN - 1560-7917

VL - 27

JO - Eurosurveillance

JF - Eurosurveillance

IS - 48

M1 - 2200894

ER -

Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

Abstract

Keywords

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Projects

FWO MPX: Op zoek naar het mechanisme achter Monkeypox virus transmissie: een multidisciplinaire 'one health' studie over een opkomende zoönose

Cite this