Severe multifocal form of Buruli ulcer after Streptomycin and Rifampin treatment: comments on possible dissemination mechanisms

GE Sopoh, AD Dossou, LV Brun, YT Barogui, JG Houezo, D Affolabi, SY Anagonou, RC Johnson, L Kestens, F Portaels

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Buruli ulcer (BU), a disease caused by Mycobacterium ulcerans, leads to the destruction of skin and sometimes bone. Here, we report a case of severe multifocal BU with osteomyelitis in a 6-year-old human immunodeficiency virus (HIV)-negative boy. Such disseminated forms are poorly documented and generally occur in patients with HIV co-infection. The advent of antibiotic treatment with streptomycin (S) and rifampin (R) raised hope that these multifocal BU cases could be reduced. The present case raises two relevant points about multifocal BU: the mechanism of dissemination that leads to the development of multiple foci and the difficulties of treatment of multifocal forms of BU. Biochemical (hypoproteinemia), hematological (anemia), clinical (traditional treatment), and genetic factors are discussed as possible risk factors for dissemination
    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume83
    Issue number2
    Pages (from-to)307-313
    Number of pages7
    ISSN0002-9637
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Bacterial diseases
    • Buruli ulcer
    • Mycobacterium ulcerans
    • Case reports
    • Treatment
    • Streptomycin
    • Rifampin
    • Treatment outcome
    • Multifocal
    • Severe infection
    • Osteomyelitis
    • Lesions
    • Dissemination
    • Benin
    • Africa-West

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